Distinct cytotoxic mechanisms of pristine versus hydroxylated fullerene
A Isakovic, Z Markovic… - Toxicological …, 2006 - academic.oup.com
The mechanisms underlying the cytotoxic action of pure fullerene suspension (nano-C60)
and water-soluble polyhydroxylated fullerene [C60 (OH) n] were investigated. Crystal violet …
and water-soluble polyhydroxylated fullerene [C60 (OH) n] were investigated. Crystal violet …
A review of the electrophilic reaction chemistry involved in covalent protein binding relevant to toxicity
SJ Enoch, CM Ellison, TW Schultz… - Critical reviews in …, 2011 - Taylor & Francis
Several pieces of legislation have led to an increased interest in the use of in silico methods,
specifically the formation of chemical categories for the assessment of toxicological …
specifically the formation of chemical categories for the assessment of toxicological …
[HTML][HTML] Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action
TO Elufioye, S Habtemariam - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Liver diseases such as hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma are one of
the major health challenges in the world and many conditions such as inadequate nutrition …
the major health challenges in the world and many conditions such as inadequate nutrition …
Phenolic compounds protect HepG2 cells from oxidative damage: relevance of glutathione levels
In the present work, the potential hepatoprotective effects of five phenolic compounds
against oxidative damages induced by tert-butyl hydroperoxide (t-BHP) were evaluated in …
against oxidative damages induced by tert-butyl hydroperoxide (t-BHP) were evaluated in …
Pathophysiological basis for antioxidant therapy in chronic liver disease
J Medina, R Moreno-Otero - Drugs, 2005 - Springer
Oxidative stress is a common pathogenetic mechanism contributing to initiation and
progression of hepatic damage in a variety of liver disorders. Cell damage occurs when …
progression of hepatic damage in a variety of liver disorders. Cell damage occurs when …
The role of chemokines in acute liver injury
Y Saiman, SL Friedman - Frontiers in physiology, 2012 - frontiersin.org
Chemokines are small molecular weight proteins primarily known to drive migration of
immune cell populations. In both acute and chronic liver injury, hepatic chemokine …
immune cell populations. In both acute and chronic liver injury, hepatic chemokine …
Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease
Human nonalcoholic fatty liver disease (NAFLD) associated with obesity is characterized by
depletion of hepatic n-3 long-chain polyunsaturated fatty acids (LCPUFA), with lower …
depletion of hepatic n-3 long-chain polyunsaturated fatty acids (LCPUFA), with lower …
Drug bioactivation covalent binding to target proteins and toxicity relevance
A number of therapeutic drugs with different structures and mechanisms of action have been
reported to undergo metabolic activation by Phase I or Phase II drug-metabolizing enzymes …
reported to undergo metabolic activation by Phase I or Phase II drug-metabolizing enzymes …
Naturally occurring Nrf2 activators: potential in treatment of liver injury
Oxidative stress plays a major role in acute and chronic liver injury. In hepatocytes, oxidative
stress frequently triggers antioxidant response by activating nuclear erythroid 2‐related …
stress frequently triggers antioxidant response by activating nuclear erythroid 2‐related …
[HTML][HTML] Betaine treatment protects liver through regulating mitochondrial function and counteracting oxidative stress in acute and chronic animal models of hepatic …
R Heidari, H Niknahad, A Sadeghi… - Biomedicine & …, 2018 - Elsevier
Betaine is a derivative of the amino acid glycine widely investigated for its hepatoprotective
properties against alcoholism. The protective properties of betaine in different other …
properties against alcoholism. The protective properties of betaine in different other …