The complex architecture of the liver is intertwined with its response to xenobiotic
compounds. In particular, hepatocyte subpopulations are distributed along the sinusoid in …

Abstract Cytochrome P450 (CYP) induction-mediated interaction is one of the major
concerns in clinical practice and for the pharmaceutical industry. There are two major issues …

Cisplatin is a potent and widely used chemotherapeutic agent. Nephrotoxicity induced by
this drug has been well documented. However, very little information is available on cisplatin …

Drugs are usually biotransformed into new chemical species that may have either toxic or
therapeutic effects. Drug metabolism studies are routinely performed in laboratory animals …

Dichlorodiphenyltrichloroethane (DDT) is still used in certain areas of tropics and subtropics
to control malaria and other insect-transmitted diseases. DDT and its metabolites have been …

The proinflammatory cytokine TNF has a pivotal role in liver pathophysiology because it
holds the capacity to induce both hepatocyte cell death and hepatocyte proliferation. This …

Introduction 2.1. Alcohol liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD)
2.2. Mechanisms of apoptosis 2.3. Apoptosis and the liver 3. Hepatocyte apoptosis in ALD …

Acetaminophen (APAP) overdose is a leading cause of acute liver failure worldwide, in
which mitochondrial DNA (mtDNA) released by damaged hepatocytes activates neutrophils …

CD95 ligand (CD95L) triggers a rapid formation of reactive oxygen species (ROS) as an
upstream event of CD95 activation and apoptosis induction in rat hepatocytes. This ROS …

While drug toxicity (especially hepatotoxicity) is the most frequent reason cited for
withdrawal of an approved drug, no simple solution exists to adequately predict such …