The NHE family of ion exchangers includes six isoforms (NHE1–NHE6) that function in an
electroneutral exchange of intracellular H+ for extracellular Na+. This review focuses on the …

Four isoforms of the Na+/H+ exchanger (NHE6–NHE9) are distributed to intracellular
compartments in human cells. They are localized to Golgi and post-Golgi endocytic …

Ejection of intracellular H in exchange for external Na is the most effective means of
eliminating excess acid from actively metabolizing cells. Na/H exchange is also crucial for …

In recent years, it has become evident that the volume of a given cell is an important factor
not only in defining its intracellular osmolality and its shape, but also in defining other …

▪ Abstract The sodium/hydrogen exchange (NHE) gene family plays an integral role in
neutral sodium absorption in the mammalian intestine. The NHE gene family is comprised of …

This review describes recent progress concerning the molecular aspects of the Na+/H+
exchanger. The Na+/H+ exchanger is an important regulator for intracellular pH, cell volume …

NHE3 is the Na+/H+ exchanger located on the intestinal and renal brush border membrane,
where it functions in transepithelial Na+ absorption. The brush border Na+ absorptive …

The SLC9 gene family encodes Na+/H+ exchangers (NHEs). These transmembrane
proteins transport ions across lipid bilayers in a diverse array of species from prokaryotes to …

Background & Aims: Collagenous colitis is an inflammatory disease of unknown etiology
with diarrhea as the leading symptom. The aim of this study was to examine the pathogenic …

Despite unfavorable conditions, a single species of fish, Osorezan dace, lives in an
extremely acidic lake (pH 3.5) in Osorezan, Aomori, Japan. Physiological studies have …