The intestinal tract faces numerous challenges that require several layers of defence. The
tight epithelium forms a physical barrier that is further protected by a mucus layer, which …

The colon mucus layer is organized with an inner colon mucus layer that is impenetrable to
bacteria and an outer mucus layer that is expanded to allow microbiota colonization. A major …

Biogeography is the study of species distribution and diversity within an ecosystem and is at
the core of how we understand ecosystem dynamics and interactions at the macroscale. In …

Background & Aims Single-cell transcriptomics offer unprecedented resolution of tissue
function at the cellular level, yet studies analyzing healthy adult human small intestine and …

Abstract The mucin2 (MUC2) mucus barrier acts as the first barrier that prevents direct
contact between intestinal bacteria and colonic epithelial cells. Bacterial factors related to …

Simple Summary The gastrointestinal tract is a complex organization of various types of
epithelial cells forming a single layer of the mucosal barrier, the host mucosal immune …

The human intestinal microbiome has coevolved with its host to establish a stable
homeostatic relationship with hallmark features of mutualistic symbioses, yet the mechanistic …

Neuroepithelial crosstalk is critical for gut physiology. However, the mechanisms by which
sensory neurons communicate with epithelial cells to mediate gut barrier protection at …

Colonic goblet cells are specialized epithelial cells that secrete mucus to physically separate
the host and its microbiota, thus preventing bacterial invasion and inflammation. How goblet …

The intestinal tract is an ecosystem in which the resident microbiota lives in symbiosis with
its host. This symbiotic relationship is key to maintaining overall health, with dietary habits of …