Microglia autophagy in ischemic stroke: A double-edged sword

L Peng, G Hu, Q Yao, J Wu, Z He, BYK Law… - Frontiers in …, 2022 - frontiersin.org
Ischemic stroke (IS) is one of the major types of cerebrovascular diseases causing
neurological morbidity and mortality worldwide. In the pathophysiological process of IS …

Update on mechanisms of the pathophysiology of neonatal encephalopathy

JO Davidson, F Gonzalez, P Gressens, AJ Gunn… - Seminars in Fetal and …, 2021 - Elsevier
Therapeutic hypothermia is now well established to significantly improve survival without
disability after neonatal encephalopathy (NE). To further improve outcomes, we need to …

The role of the interleukin-1 family in complications of prematurity

EA Green, SP Garrick, B Peterson, PJ Berger… - International Journal of …, 2023 - mdpi.com
Preterm birth is a major contributor to neonatal morbidity and mortality. Complications of
prematurity such as bronchopulmonary dysplasia (BPD, affecting the lung), pulmonary …

Newly identified deficiencies in the multiple sclerosis central nervous system and their impact on the remyelination failure

G Scalabrino - Biomedicines, 2022 - mdpi.com
The pathogenesis of multiple sclerosis (MS) remains enigmatic and controversial. Myelin
sheaths in the central nervous system (CNS) insulate axons and allow saltatory nerve …

Overexpression of miR-199a-5p improves brain injury in newborn rats with intrauterine infection via inhibition of astrocyte activation

F Xie, L Li, M Peng, H Zhang - Brain Research, 2023 - Elsevier
White matter injury is the most common form of brain injury in preterm infants. In addition to
hypoxia ischemia, intrauterine infection is most closely related to brain white matter injury …

Oligodendrocyte progenitor cells' fate after neonatal asphyxia—Puzzling implications for the development of hypoxic–ischemic encephalopathy

J Janowska, J Gargas, K Zajdel, M Wieteska… - Brain …, 2024 - Wiley Online Library
Premature birth or complications during labor can cause temporary disruption of cerebral
blood flow, often followed by long‐term disturbances in brain development called hypoxic …

[HTML][HTML] Timed fetal inflammation and postnatal hypoxia cause cortical white matter injury, interneuron imbalances, and behavioral deficits in a double-hit rat model of …

MJV Brandt, CM Kosmeijer, EJM Achterberg… - Brain, Behavior, & …, 2024 - Elsevier
Extreme preterm birth-associated adversities are a major risk factor for aberrant brain
development, known as encephalopathy of prematurity (EoP), which can lead to long-term …

Modulatory effect of IL‐1 inhibition following lipopolysaccharide‐induced neuroinflammation in neonatal microglia and astrocytes

WC Pierre, I Londono, C Quiniou… - International Journal …, 2022 - Wiley Online Library
Introduction Inflammation‐induced white matter injury (WMI) in preterm infants is
characterized by microglia activation, astrogliosis, oxidative stress and neurodevelopmental …

Rationale for the Use of Cord Blood in Hypoxic‐Ischaemic Encephalopathy

I Zdolińska-Malinowska, D Boruczkowski… - Stem Cells …, 2022 - Wiley Online Library
Hypoxic‐ischaemic encephalopathy (HIE) is a severe complication of asphyxia at birth.
Therapeutic hypothermia, the standard method for HIE prevention, is effective in only 50% of …

Mechanistic advances of hyperoxia-induced immature brain injury

Y Song, C Yang - Heliyon, 2024 - cell.com
The impact of hyperoxia-induced brain injury in preterm infants is being increasingly
investigated. However, the parameters and protocols used to study this condition in animal …