The mucosal tissues of the gastrointestinal, respiratory, reproductive, and urinary tracts, and
the surface of the eye present an enormous surface area to the exterior environment. All of …

Gastric cancer is a major health burden and is the fifth most common malignancy and the
third most common cause of death from cancer worldwide. Development of gastric cancer …

The presence of spiral-shaped bacteria on human gastric mucosa was first recognized
nearly one hundred years ago (Pel, 1899). These bacteria were isolated for the first time in …

Mucin glycoproteins are secreted in large quantities by mucosal epithelia and cell surface
mucins are a prominent feature of the glycocalyx of all mucosal epithelia. Currently, studies …

In clinical settings, Lactobacillus johnsonii La1 administration has been reported to have a
favorable effect on Helicobacter pylori-associated gastritis, although the mechanism remains …

Helicobacter pylori (H. pylori) is one of the most important factors that affect the development
of gastric cancer, and its mechanism remains un-elucidated. Our present study found that …

At a molecular level, the genesis of HBV-induced HCC is a complex, multifaceted, and
multistep process with the essential components being a series of genetic or epigenetic …

Highlights What are the main findings? Mucus, as the most widely distributed biofilm and
vital protective barrier on the surface of mucous membranes throughout the body, fulfills a …

Background: Helicobacter pylori infection is one of the major causes of human gastric
carcinoma and can disturb the gastric mucosa barrier. Mucins have not only lubricating and …

Animal models are essential for in vivo analysis of Helicobacter-related diseases.
Transgenic mice and Mongolian gerbil models have been the corner stone of present …