Purinergic receptors (Rs) of the ATP/ADP, UTP/UDP (P2X, P2Y) and adenosine (A1, A2A)-
sensitive classes broadly interfere with cognitive processes both under quasi normal and …

Macropore formation and current facilitation are intriguing phenomena associated with ATP-
gated P2X7 receptors (P2X7). Macropores are large pores formed in the cell membrane that …

Introduction: Sepsis is defined as a multifactorial debilitating condition with high risks of
death. The intense inflammatory response causes deleterious effects on the brain, a …

The discovery of the P2X7 receptor (P2X7R, originally named P2Z) in immune cells, its
cloning, and the identification of its role in a multiplicity of immune-mediated diseases raised …

Abstract Ecto‐5′‐nucleotidase/CD73 (eN/CD73) is a membrane‐bound enzyme involved
in extracellular production of adenosine and a cell adhesion molecule involved in cell–cell …

Increased ATP release and its extracellular catabolism through CD73 (ecto-5′-
nucleotidase) lead to the overactivation of adenosine A2A receptors (A2AR), which occurs in …

Aging is associated with cognitive decline via incompletely understood mechanisms.
Cerebral microvascular dysfunction occurs in aging, particularly impaired endothelium …

The blood–brain barrier (BBB) is a biological barrier that protects the central nervous system
(CNS) by ensuring an appropriate microenvironment. Brain microvascular endothelial cells …

Age-related macular degeneration (AMD) is a chronic and progressive inflammatory disease
of the retina characterized by photoceptor loss and significant central visual impairment due …

Abstract Extracellular adenosine 5′-triphosphate (ATP) is a vital signaling molecule
involved in various physiological processes within the body. In recent years, studies have …