[HTML][HTML] Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

The role of myofibroblasts in physiological and pathological tissue repair

R Schuster, F Younesi, M Ezzo… - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

[HTML][HTML] Cell–scaffold interactions in tissue engineering for oral and craniofacial reconstruction

F Wang, X Cai, Y Shen, L Meng - Bioactive Materials, 2023 - Elsevier
Tissue engineering (TE) is critical in oral and craniofacial reconstruction. One of the most
popular topics on the biomaterial-based tissue regeneration process may be the interaction …

[HTML][HTML] Targeting growth factor and cytokine pathways to treat idiopathic pulmonary fibrosis

H Ma, S Liu, S Li, Y Xia - Frontiers in Pharmacology, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease of unknown origin
that usually results in death from secondary respiratory failure within 2–5 years of diagnosis …

[HTML][HTML] Phytoconstituent-Loaded Nanofibrous Meshes as Wound Dressings: A Concise Review

A Sharma, D Dheer, I Singh, V Puri, P Kumar - Pharmaceutics, 2023 - mdpi.com
In the past, wounds were treated with natural materials, but modern wound dressings
include functional elements to expedite the process of healing and to improve skin recovery …

FGF/FGFR system in the central nervous system demyelinating Disease: recent progress and implications for multiple sclerosis

Q Zhang, Z Chen, K Zhang, J Zhu… - CNS Neuroscience & …, 2023 - Wiley Online Library
Background With millions of victims worldwide, multiple sclerosis is the second most
common cause of disability among young adults. Although formidable advancements have …

[HTML][HTML] FGF12 is a novel component of the nucleolar NOLC1/TCOF1 ribosome biogenesis complex

M Sochacka, R Karelus, L Opalinski… - Cell Communication and …, 2022 - Springer
Among the FGF proteins, the least characterized superfamily is the group of fibroblast growth
factor homologous factors (FHFs). To date, the main role of FHFs has been primarily seen in …

[HTML][HTML] Non-alcoholic fatty liver disease and liver secretome

MS Khan, C Lee, SG Kim - Archives of Pharmacal Research, 2022 - Springer
Metabolism of carbohydrates and lipids and protein degradation occurs in the liver and
contributes to the body's homeostasis by secreting a variety of mediators. Any imbalance in …

[HTML][HTML] Spatially resolved phosphoproteomics reveals fibroblast growth factor receptor recycling-driven regulation of autophagy and survival

J Watson, HR Ferguson, RM Brady, J Ferguson… - Nature …, 2022 - nature.com
Abstract Receptor Tyrosine Kinase (RTK) endocytosis-dependent signalling drives cell
proliferation and motility during development and adult homeostasis, but is dysregulated in …

[HTML][HTML] Elucidating Fibroblast Growth Factor–Induced Kinome Dynamics Using Targeted Mass Spectrometry and Dynamic Modeling

TS Veth, C Francavilla, AJR Heck, M Altelaar - Molecular & Cellular …, 2023 - ASBMB
Fibroblast growth factors (FGFs) are paracrine or endocrine signaling proteins that, activated
by their ligands, elicit a wide range of health and disease-related processes, such as cell …