Despite advances in neurosurgery, chemotherapy and radiotherapy, glioblastoma remains
one of the most treatment-resistant CNS malignancies, and the tumour inevitably recurs. The …

Cancer has been one of the most common life‐threatening diseases for a long time.
Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) …

Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Despite advances in biology and therapeutic modalities, existence of highly tumorigenic
glioma stem-like cells (GSCs) makes glioblastomas (GBMs) invincible. N6-methyl adenosine …

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a poor
prognosis, despite surgical resection combined with radio-and chemotherapy. The major …

Hyperthermia therapy (HT) is the exposure of a region of the body to elevated temperatures
to achieve a therapeutic effect. HT anticancer properties and its potential as a cancer …

CD44 is a cell adhesion molecule that plays an important role in tumor progression and
metastasis. The role of CD44 in tumorigenesis is due to its binding to extracellular matrix …

Simple Summary This review describes in a very detailed and exhaustive approach the
literature of these last 20 years on glioblastoma targeted therapies in Phases II-IV of 257 …

Glioblastoma (GBM) remains the most lethal and common primary brain tumor, even after
treatment with multiple therapies, such as surgical resection, chemotherapy, and radiation …

PD-L1 is critical for tumor cell escape from immune surveillance by inhibiting T cell function
via the PD-1 receptor. Accumulating evidence demonstrates that anti-PD-L1 monoclonal …