Integrative polygenic risk score improves the prediction accuracy of complex traits and diseases
Polygenic risk scores (PRSs) are an emerging tool to predict the clinical phenotypes and
outcomes of individuals. We propose PRSmix, a framework that leverages the PRS corpus …
outcomes of individuals. We propose PRSmix, a framework that leverages the PRS corpus …
A polygenic risk score for Alzheimer's disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in …
Abstract Introduction Polygenic Risk Scores (PRSs) are summaries of genetic risk alleles for
an outcome. Methods We used summary statistics from five GWASs of AD to construct PRSs …
an outcome. Methods We used summary statistics from five GWASs of AD to construct PRSs …
[PDF][PDF] Power of inclusion: Enhancing polygenic prediction with admixed individuals
Y Tanigawa, M Kellis - The American Journal of Human Genetics, 2023 - cell.com
Admixed individuals offer unique opportunities for addressing limited transferability in
polygenic scores (PGSs), given the substantial trans-ancestry genetic correlation in many …
polygenic scores (PGSs), given the substantial trans-ancestry genetic correlation in many …
Integration of risk factor polygenic risk score with disease polygenic risk score for disease prediction
H Jung, HU Jung, EJ Baek, SY Kwon, JO Kang… - Communications …, 2024 - nature.com
Polygenic risk score (PRS) is useful for capturing an individual's genetic susceptibility.
However, previous studies have not fully exploited the potential of the risk factor PRS …
However, previous studies have not fully exploited the potential of the risk factor PRS …
Haplotype Function Score improves biological interpretation and cross-ancestry polygenic prediction of human complex traits
We propose a new framework for human genetic association studies: at each locus, a deep
learning model (in this study, Sei) is used to calculate the functional genomic activity score …
learning model (in this study, Sei) is used to calculate the functional genomic activity score …
Correlation-based tests for the formal comparison of polygenic scores in multiple populations
S Gunn, KL Lunetta - Plos Genetics, 2024 - journals.plos.org
Polygenic scores (PGS) are measures of genetic risk, derived from the results of genome
wide association studies (GWAS). Previous work has proposed the coefficient of …
wide association studies (GWAS). Previous work has proposed the coefficient of …
Cross-ancestry genetic architecture and prediction for cholesterol traits
While cholesterol is essential, a high level of cholesterol is associated with the risk of
cardiovascular diseases. Genome-wide association studies (GWASs) have proven …
cardiovascular diseases. Genome-wide association studies (GWASs) have proven …
Generalizability of polygenic prediction models: how is the R2 defined on test data?
Background Polygenic risk scores (PRS) quantify an individual's genetic predisposition for
different traits and are expected to play an increasingly important role in personalized …
different traits and are expected to play an increasingly important role in personalized …
[HTML][HTML] Fine-mapping genomic loci refines bipolar disorder risk genes
Bipolar disorder (BD) is a heritable mental illness with complex etiology. While the largest
published genome-wide association study identified 64 BD risk loci, the causal SNPs and …
published genome-wide association study identified 64 BD risk loci, the causal SNPs and …
[HTML][HTML] Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction
Blood cell phenotypes are routinely tested in healthcare to inform clinical decisions. Genetic
variants influencing mean blood cell phenotypes have been used to understand disease …
variants influencing mean blood cell phenotypes have been used to understand disease …