The mechanism of HMGB1 secretion and release

R Chen, R Kang, D Tang - Experimental & molecular medicine, 2022 - nature.com
High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple
functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone …

Damage-associated molecular patterns in trauma

B Relja, WG Land - European journal of trauma and emergency surgery, 2020 - Springer
Abstract In 1994, the “danger model” argued that adaptive immune responses are driven
rather by molecules released upon tissue damage than by the recognition of “strange” …

Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation

SS Xie, Y Deng, S Guo, J Li, Y Zhou, J Liao, D Wu… - Scientific reports, 2022 - nature.com
Inflammation triggers pulmonary vascular remodelling. Ferroptosis, a nonapoptotic form of
cell death that is triggered by iron-dependent lipid peroxidation and contributes to the …

Enlightening the role of high mobility group box 1 (HMGB1) in inflammation: Updates on receptor signalling

YN Paudel, E Angelopoulou, C Piperi… - European journal of …, 2019 - Elsevier
High mobility group box 1 (HMGB1) is a ubiquitous protein, released passively by necrotic
tissues or secreted actively by stressed cells. Extracellular HMGB1 is a typical damage …

MyD88: At the heart of inflammatory signaling and cardiovascular disease

AL Bayer, P Alcaide - Journal of molecular and cellular cardiology, 2021 - Elsevier
Cardiovascular disease is a leading cause of death worldwide and is associated with
systemic inflammation. In depth study of the cell-specific signaling mechanisms mediating …

Resveratrol mediates the miR-149/HMGB1 axis and regulates the ferroptosis pathway to protect myocardium in endotoxemia mice

X Wang, A Simayi, J Fu, X Zhao… - American Journal of …, 2022 - journals.physiology.org
Endotoxemia is a common complication often used to model the acute inflammatory
response associated with endotoxemia. Resveratrol has been shown to exert a wide range …

High mobility group box 1: biological functions and relevance in oxidative stress related chronic diseases

S Taverna, A Tonacci, M Ferraro, G Cammarata… - Cells, 2022 - mdpi.com
In the early 1970s, a group of non-histone nuclear proteins with high electrophoretic mobility
was discovered and named high-mobility group (HMG) proteins. High-mobility group box 1 …

Clinoforms and clinothems: Fundamental elements of basin infill

C Pellegrini, S Patruno, W Helland‐Hansen, RJ Steel… - Basin …, 2020 - earthdoc.org
This special issue dealing with the recent advances on modern and ancient clinoform‐
stratified sedimentary successions arises from a European Geoscience Union (EGU) …

Gut microbiota profiles in children and adolescents with psychiatric disorders

M Soltysova, A Tomova, D Ostatnikova - Microorganisms, 2022 - mdpi.com
The aim of our work is to summarize the current state of knowledge on gut microbiota
differences in children and adolescents with psychiatric disorders. To find the relevant …

Arsenic-induced lung inflammation and fibrosis in a rat model: Contribution of the HMGB1/RAGE, PI3K/AKT, and TGF-β1/SMAD pathways

W Wang, F Zheng, A Zhang - Toxicology and Applied Pharmacology, 2021 - Elsevier
An increasing number of studies have shown that arsenic exposure increases the risk of
lung cancer as well as a variety of non-malignant respiratory diseases, including bronchitis …