HIV, the causative agent of AIDS, has a complex evolutionary history involving several cross-
species transmissions and recombination events as well as changes in the repertoire and …

Human and simian immunodeficiency viruses (HIVs and SIVs, respectively) encode several
small proteins (Vif, Vpr, Nef, Vpu, and Vpx) that are called accessory because they are not …

The host proteins, SERINC3 and SERINC5, have been recently shown to incorporate into
HIV-1 particles and compromise their ability to fuse with target cells, an effect that is …

The primate lentiviral accessory protein Nef downregulates CD4 and major
histocompatibility complex class I (MHC-I) from the cell surface via independent endosomal …

Extracellular vesicles (EVs) or exosomes have been implicated in the pathophysiology of
infections and cancer. The negative regulatory factor (Nef) encoded by simian …

The host-cell restriction factor SERINC5 potently suppresses the infectivity of HIV, type 1
(HIV-1) particles, and is counteracted by the viral pathogenesis factor Nef. However, the …

Recent commercialization of lentiviral vector (LV)-based cell therapies and successful
reports of clinical studies have demonstrated the untapped potential of LVs to treat diseases …

ABSTRACT Serine incorporator 5 (SERINC5) is a recently identified restriction factor that
strongly blocks HIV-1 entry but is counteracted by Nef. Notably, tier 1 HIV-1 Env proteins are …

HIV-1, the main causative agent of AIDS, and related primate lentiviruses show a striking
ability to efficiently replicate throughout the lifetime of an infected host. In addition to their …

Macroautophagy/autophagy is an auto-digestive pro-survival pathway activated in response
to stress to target cargo for lysosomal degradation. In recent years, autophagy has become …