[HTML][HTML] Nef obtained from individuals with HIV-1 vary in their ability to antagonize SERINC3-and SERINC5-mediated HIV-1 restriction
Z Kruize, AC van Nuenen, SW van Wijk, AF Girigorie… - Viruses, 2021 - mdpi.com
Nef is a multifunctional viral protein that has the ability to downregulate cell surface
molecules, including CD4 and major histocompatibility complex class I (MHC-I) and, as …
molecules, including CD4 and major histocompatibility complex class I (MHC-I) and, as …
Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility
EPF Chu, CM Elso, AH Pollock, MA Alsayb… - Molecular …, 2017 - Elsevier
During immune cell activation, serine-derived lipids such as phosphatidylserine and
sphingolipids contribute to the formation of protein signaling complexes within the plasma …
sphingolipids contribute to the formation of protein signaling complexes within the plasma …
Preadaptation of simian immunodeficiency virus SIVsmm facilitated Env-mediated counteraction of human tetherin by human immunodeficiency virus type 2
E Heusinger, K Deppe, P Sette, C Krapp… - Journal of …, 2018 - Am Soc Microbiol
The host restriction factor tetherin inhibits virion release from infected cells and poses a
significant barrier to successful zoonotic transmission of primate lentiviruses to humans …
significant barrier to successful zoonotic transmission of primate lentiviruses to humans …
CD4-and time-dependent susceptibility of HIV-1-infected cells to antibody-dependent cellular cytotoxicity
ABSTRACT HIV-1-specific antibody-dependent cellular cytotoxicity (ADCC) antibodies
within HIV-1-positive (HIV-1+) individuals predominantly target CD4-induced (CD4i) …
within HIV-1-positive (HIV-1+) individuals predominantly target CD4-induced (CD4i) …
The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists
P de Sousa-Pereira, J Abrantes… - Journal of General …, 2019 - microbiologyresearch.org
A first step towards the development of a human immunodeficiency virus (HIV) animal model
has been the identification and surmounting of species-specific barriers encountered by HIV …
has been the identification and surmounting of species-specific barriers encountered by HIV …
[HTML][HTML] A Conserved Acidic Residue in the C-Terminal Flexible Loop of HIV-1 Nef Contributes to the Activity of SERINC5 and CD4 Downregulation
The host transmembrane protein SERINC5 is incorporated into retrovirus particles and
inhibits HIV-1 infectivity. The lentiviral Nef protein counteracts SERINC5 by downregulating it …
inhibits HIV-1 infectivity. The lentiviral Nef protein counteracts SERINC5 by downregulating it …
[HTML][HTML] Loss of tetherin antagonism by Nef impairs SIV replication during acute infection of rhesus macaques
A Tavakoli-Tameh, SK Janaka, K Zarbock… - PLoS …, 2020 - journals.plos.org
Most simian immunodeficiency viruses use Nef to counteract the tetherin proteins of their
nonhuman primate hosts. Nef also downmodulates cell-surface CD4 and MHC class I (MHC …
nonhuman primate hosts. Nef also downmodulates cell-surface CD4 and MHC class I (MHC …
Selective Disruption of SERINC5 Antagonism by Nef Impairs Simian Immunodeficiency Virus Replication in Primary CD4+ T Cells
SK Janaka, AV Palumbo, A Tavakoli-Tameh… - Journal of …, 2021 - Am Soc Microbiol
The Nef proteins of human immunodeficiency virus type 1 (HIV-1) and simian
immunodeficiency virus (SIV) enhance viral infectivity by preventing the incorporation of the …
immunodeficiency virus (SIV) enhance viral infectivity by preventing the incorporation of the …
Maintenance of AP-2-dependent functional activities of Nef restricts pathways of immune escape from CD8 T lymphocyte responses
B Schouest, AM Weiler, SK Janaka, TA Myers… - Journal of …, 2018 - Am Soc Microbiol
Nef-specific CD8+ T lymphocytes (CD8TL) are linked to extraordinary control of primate
lentiviral replication, but the mechanisms underlying their efficacy remain largely unknown …
lentiviral replication, but the mechanisms underlying their efficacy remain largely unknown …
APOBEC3F Constitutes a Barrier to Successful Cross-Species Transmission of Simian Immunodeficiency Virus SIVsmm to Humans
Simian immunodeficiency virus infecting sooty mangabeys (SIVsmm) has been transmitted
to humans on at least nine occasions, giving rise to human immunodeficiency virus type 2 …
to humans on at least nine occasions, giving rise to human immunodeficiency virus type 2 …