RNA ac4C modification is a novel and rare chemical modification observed in mRNA.
Traditional biochemical studies had primarily associated ac4C modification with tRNA and …

Alternative splicing greatly expands the transcriptomic and proteomic diversities related to
physiological and developmental processes in higher eukaryotes. Splicing of long …

Precursor messenger RNA (pre-mRNA) splicing is a fundamental step in eukaryotic gene
expression that systematically removes non-coding regions (introns) and ligates coding …

Dozens of incurable neurological disorders result from expansion of short repeat sequences
in both coding and non-coding regions of the transcriptome. Short repeat expansions …

Myotonic dystrophy type 2 (DM2) is one of> 40 microsatellite disorders caused by RNA
repeat expansions. The DM2 repeat expansion, r (CCUG) exp (where “exp” denotes …

Many diseases are caused by toxic RNA repeats. Herein, we designed a lead small
molecule that binds the structure of the r (CUG) repeat expansion [r (CUG) exp] that causes …

Over recent years, long-range RNA structure has emerged as a factor that is fundamental to
alternative splicing regulation. An increasing number of human disorders are now being …

The hexanucleotide repeat expansion GGGGCC [r (G4C2) exp] within intron 1 of C9orf72
causes genetically defined amyotrophic lateral sclerosis and frontotemporal dementia …

Abstract Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder
caused by a CAG repeat expansion in the ATXN3 gene encoding the ataxin-3 protein …

Alternative splicing generates a myriad of RNA products and protein isoforms of different
functions from a single gene. Dysregulated alternative splicing has emerged as a new …