Pharmacogenetic factors affecting asthma treatment response. potential implications for drug therapy

JM García-Menaya, C Cordobés-Durán… - Frontiers in …, 2019 - frontiersin.org
Asthma is a frequent disease, mainly characterized by airway inflammation, in which drug
therapy is crucial in its management. The potential of pharmacogenomics testing in asthma …

Glucocorticoid therapy in respiratory illness: bench to bedside

DA Amratia, H Viola… - Journal of Investigative …, 2022 - journals.sagepub.com
Each year, hundreds of millions of individuals are affected by respiratory disease leading to
approximately 4 million deaths. Most respiratory pathologies involve substantially …

School nurse asthma program reduces healthcare utilization in children with persistent asthma

M Trivedi, J Patel, D Lessard, T Kremer, N Byatt… - Journal of …, 2018 - Taylor & Francis
Objective: We examined the impact of a novel, school nurse-supervised asthma therapy
program on healthcare utilization. Methods: We retrospectively reviewed charts of 84 …

A pilot school-based health center intervention to improve asthma chronic care in high-poverty schools

LC Holmes, H Orom, HK Lehman, S Lampkin… - Journal of …, 2022 - Taylor & Francis
Objective To test the feasibility and effectiveness of a multifaceted intervention administered
through school-based health centers (SBHCs) to improve asthma control for children in high …

Novel pyrrolidine derivatives of budesonide as long acting inhaled corticosteroids for the treatment of pulmonary inflammatory diseases

E Ghidini, G Marchini, AM Capelli… - Journal of Medicinal …, 2018 - ACS Publications
Inhaled corticosteroids (ICSs) represent the first line therapy for the treatment of asthma and
are also extensively utilized in chronic obstructive pulmonary disease. Our goal was to …

Will precision medicine be available for all patients in the near future?

RM Gómez, I Ansotegui… - Current Opinion in Allergy …, 2019 - journals.lww.com
Precision medicine encompasses a personalized care of the patient, the prediction of a
successful treatment, the potential prevention of a disease and its progression when present …

Active ingredients of epimedii folium and ligustri lucidi fructus balanced GR/HSP90 to improve the sensitivity of asthmatic rats to budesonide

X Tang, X Li, H Nian, Y Yang, Y Chen… - Evidence‐Based …, 2017 - Wiley Online Library
This study aimed to investigate the possible molecular mechanisms of active ingredients of
Epimedii Folium (EF) and Ligustri Lucidi Fructus (LLF) combined with Budesonide (Bun) in …

[PDF][PDF] 靶向于Galectin-10 蛋白的哮喘抑制剂设计

李南星, 张麟 - 化工学报, 2021 - hgxb.cip.com.cn
Galectin-10 (Gal10) 存在于人类嗜酸性细胞中, 可经历相变成为晶体而诱发哮喘疾病.
通过分子动力学模拟方法结合分子力学-泊松-玻尔兹曼方程-表面积计算自由能分解方法解析 …

Studies of molecular pathways associated with blood neutrophil corticosteroid insensitivity in equine asthma

SP Dogaheh, R Boivin, JP Lavoie - Veterinary Immunology and …, 2021 - Elsevier
Severe equine asthma is characterized by airway hyperresponsiveness, neutrophilic
inflammation and structural alterations of the lower airways. In asthmatic horses with …

The role of supervised school therapy in poorly controlled asthma in children

M Raju, M Sagar, A Bush, E Quaye… - Baylor University …, 2023 - Taylor & Francis
Background In children, nonadherence to inhaled corticosteroid (ICS) therapy leads to poor
asthma control and complications. Methods We evaluated the benefit from initiation of ICS …