TGF-β pathways in aging and immunity: lessons from Caenorhabditis elegans

KK Yamamoto, C Savage-Dunn - Frontiers in Genetics, 2023 - frontiersin.org
The Transforming Growth Factor-β (TGF-β) superfamily of signaling molecules plays critical
roles in development, differentiation, homeostasis, and disease. Due to the conservation of …

The Caenorhabditis elegans cuticle and precuticle: a model for studying dynamic apical extracellular matrices in vivo

MV Sundaram, N Pujol - Genetics, 2024 - academic.oup.com
Apical extracellular matrices (aECMs) coat the exposed surfaces of animal bodies to shape
tissues, influence social interactions, and protect against pathogens and other …

TGF-β1 suppresses the T-cell response in teleost fish by initiating Smad3-and Foxp3-mediated transcriptional networks

Q Zhang, M Geng, K Li, H Gao, X Jiao, K Ai… - Journal of Biological …, 2023 - ASBMB
Transforming growth factor-β1 (TGF-β1) can suppress the activation, proliferation, and
function of many T-cell subsets, protecting organisms from inflammatory and autoimmune …

Evolution and diversity of TGF-β pathways are linked with novel developmental and behavioral traits

WS Lo, M Roca, M Dardiry, M Mackie… - Molecular Biology …, 2022 - academic.oup.com
Transforming growth factor-β (TGF-β) signaling is essential for numerous biologic functions.
It is a highly conserved pathway found in all metazoans including the nematode …

Condensed tannins act as anthelmintics by increasing the rigidity of the nematode cuticle

L Greiffer, E Liebau, FC Herrmann, V Spiegler - Scientific Reports, 2022 - nature.com
Tannins and tanniferous plant extracts have been discussed as sustainable means for
helminth control in the past two decades in response to a dramatic increase of resistances …

Advancing insights into microgravity induced muscle changes using Caenorhabditis elegans as a model organism

LJ Beckett, PM Williams, LS Toh, V Hessel… - npj …, 2024 - nature.com
Spaceflight presents significant challenges to the physiological state of living organisms.
This can be due to the microgravity environment experienced during long-term space …

ADARs regulate cuticle collagen expression and promote survival to pathogen infection

A Dhakal, C Salim, M Skelly, Y Amichan, AT Lamm… - BMC biology, 2024 - Springer
Background In all organisms, the innate immune system defends against pathogens through
basal expression of molecules that provide critical barriers to invasion and inducible …

Regulation of miR-61 and col-19 via TGF-β and Notch signalling in Caenorhabditis elegans against Klebsiella aerogenes infection

T Gowripriya, KM Afrin, M Paurna, R Yashwanth… - Microbial …, 2024 - Elsevier
Klebsiella aerogenes, previously known as Enterobacter aerogenes, is a gram-negative
bacterium typically present in the gastrointestinal tract. While numerous studies reported the …

An Emerging Animal Model for Querying the Role of Whole Genome Duplication in Development, Evolution, and Disease

M Schvarzstein, F Alam, M Toure… - Journal of Developmental …, 2023 - mdpi.com
Whole genome duplication (WGD) or polyploidization can occur at the cellular, tissue, and
organismal levels. At the cellular level, tetraploidization has been proposed as a driver of …

Transforming growth factor‐β family biology: From basic mechanisms to roles in development and disease.

JL Christian, CS Hill - Developmental Dynamics, 2022 - search.ebscohost.com
Beginning with the ligands, Rifkin et al. 1 discuss the latent TGF-binding proteins (LTBPs)
with respect to their role in regulating TGF-ligand activity. The transforming growth factor …