RhoGDI2 is a guanine nucleotide dissociation inhibitor (GDI) specific for the Rho family of
small GTPases that plays dual opposite roles in tumor progression, being both a promoter in …

Numerous post-translational modifications have been identified in histones. Most of these
occur within the histone tails, but a few have been identified within the histone core …

RhoGDI2 is a guanine nucleotide dissociation inhibitor (GDI) specific for the Rho family of
small GTPases. It is highly expressed in hematopoietic cells but is also present in a large …

ABT-263 inhibits the antiapoptotic proteins Bcl-2, Bcl-xL, and Bcl-w and has single-agent
efficacy in numerous small cell lung carcinoma (SCLC) and leukemia/lymphoma cell lines in …

Abstract miR-34a is transcriptionally induced by the tumor suppressor gene p53, which is
often downregulated in non-small cell lung cancer (NSCLC). To address whether the …

AMPylation (adenylylation) is a recently discovered mechanism employed by infectious
bacteria to regulate host cell signaling. However, despite significant effort, only a few host …

Small G proteins (eg, Rac1) play critical regulatory roles in islet β-cell function in health
(physiological insulin secretion) and in metabolic stress (cell dysfunction and demise) …

There are no targeted therapeutic modalities for triple-negative breast cancer (TNBC), thus it
is associated with poor prognosis and worst clinical outcome. Here, our aim was to identify …

Leukemia is a type of disease in which hematopoietic stem cells proliferate clonally at the
genetic level. We discovered previously by high‐resolution mass spectrometry that diallyl …

The 7-oxysterols are recognised as strong enhancers of inflammatory processes in foamy
macrophages. Atheroma-relevant 7-oxysterol mixtures induce a mixed type of cell death in …