Liver fibrosis resulting from chronic liver injury can progress to cirrhosis and liver failure.
Current treatments are limited, creating an urgent need for novel antifibrotic therapies …

Ferroptosis is an emerging type of regulated cell death usually accompanied by the
accumulation of ferrous ions (Fe2+) and lipid peroxides. As the metabolic hub of the body …

Liver fibrosis is primarily driven by the activation of hepatic stellate cells (HSCs), a process
associated with ferroptosis. Ginsenoside Rb1 (GRb1), a major active component extracted …

Ophiopogonis Radix is a well-known Traditional Chinese Medicine and functional food that
is rich in polysaccharides and has fructan as a characteristic component. In this study, an …

Background The impact of chronic hepatic infection on antigen non-specific immune cells in
circulation remains poorly understood. We reported lasting global hyperfunction of …

Liver fibrosis is a chronic liver condition that can eventually lead to cirrhosis.
Eicosapentaenoic acid (EPA, C20: 5n-3), has shown promise in alleviating liver injury …

Hepatic stellate cells (HSCs) play central roles in liver disease pathogenesis, spanning
steatosis to cirrhosis and hepatocellular carcinoma. These cells, located in the liver's …

The foreign body response (FBR) and organ fibrosis are complex biological processes
involving the interaction between macrophages and fibroblasts. Understanding the …

Eph receptor tyrosine kinase EphB1/2 contributes to the development of liver fibrosis,
suggesting the rationale that EphB1/2 inhibitors may be effective in liver fibrosis therapy …

Background TGF-β1 and SMAD3 are particularly pathogenic in the progression of renal
fibrosis. Aim This study aimed to evaluate the kidney protective potentials of silymarin (SM) …