Patients with inflammatory bowel disease (IBD) suffer from depression at higher rates than
the general population. An etiological trigger of depressive symptoms is theorised to be …

Crohn's disease (CD) and ulcerative colitis (UC) are the two main forms of inflammatory
bowel disease (IBD). Among the various immune cells involved in IBD, neutrophils are the …

The extracellular matrix (ECM) is a highly dynamic and complex network structure, which
exists in almost all tissues and is the microenvironment that cells rely on for survival. ECM …

Antibody-based therapeutics have become a major class of therapeutics with over 120
recombinant antibodies approved or under review in the EU or US. This therapeutic class …

Background & aims We aimed to model infliximab (IFX) pharmacokinetics (PK) in pediatric
acute severe ulcerative colitis (ASUC) and assess the association between PK parameters …

Polymorphonuclear neutrophils (PMNs) play a critical role in clearing invading microbes and
promoting tissue repair following infection/injury. However, dysregulated PMN trafficking and …

Therapeutic antibodies have realized substantial clinical benefits in alleviating rheumatoid
arthritis (RA) development, yet suffer formidable challenges related to their proteolytic …

Elafin and its precursor trappin‐2 are known for their contribution to the physiological
mucosal shield against luminal microbes. Such a contribution seems to be particularly …

Neutrophils are short-lived cells that play a crucial role in inflammation. As in other tissues,
these polymorphonuclear phagocytes are involved in the intestinal inflammatory response …

The in vivo presence of triacylglycerol hydroperoxide (TGOOH), a primary oxidation product
of triacylglycerol (TG), has been speculated to be involved in various diseases. Thus …