Cerebral malaria is among the major causes of malaria-associated mortality and effective
adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes …

Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

The delivery of many potentially therapeutic and diagnostic compounds to specific areas of
the brain is restricted by brain barriers, of which the most well known are the blood–brain …

In light of the recent controversies over the role of animal models for research into the
development of new treatments for severe malaria, particularly cerebral disease, a group of …

We examined the brains of 50 Malawian children who satisfied the clinical definition of
cerebral malaria (CM) during life; 37 children had sequestration of infected red blood cells …

The concept of immune privilege of the central nervous system (CNS) has dominated the
study of inflammatory processes in the brain. However, clinically relevant models have …

Plasmodium falciparum causes the most severe form of malaria and is responsible for
essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes …

Regulation of endocytic transport is controlled by an elaborate network of proteins. Rab GTP-
binding proteins and their effectors have well-defined roles in mediating specific endocytic …

After a successful invasion, malaria parasite Plasmodium falciparum extensively remodels
the infected erythrocyte cellular architecture, conferring cytoadhesive properties to the …

Coevolution of humans and malaria parasites has generated an intricate balance between
the immune system of the host and virulence factors of the parasite, equilibrating maximal …