Protein kinases regulate nearly all aspects of cell life, and alterations in their expression, or
mutations in their genes, cause cancer and other diseases. Here, we review the remarkable …

The amide functional group plays a key role in the composition of biomolecules, including
many clinically approved drugs. Bioisosterism is widely employed in the rational …

New blood vessels formation from the existing vasculature is called angiogenesis. It is an
essential physiological process for the growth of cells, tissue repair, wound healing, and …

The COVID-19 pandemic represents an unprecedented challenge for the researchers to
offer safe, tolerable, and effective treatment strategies for its causative agent known as …

Leukemia is a clonal proliferation of hematopoietic stem cells in the bone marrow. The four
broad subtypes most likely to be encountered by primary care physicians are acute …

Genomic structural variation (SV), a common hallmark of cancer, has important predictive
and therapeutic implications. However, accurately detecting SV using high-throughput …

Drug repositioning is the process of developing new indications for existing drugs or
biologics. Increasing interest in drug repositioning has occurred due to sustained high …

Cytochrome P450 2C9 (CYP2C9) is one of the most abundant CYP enzymes in the human
liver. CYP2C9 metabolizes more than 100 therapeutic drugs, including tolbutamide …

Creating a magic bullet that can selectively kill cancer cells while sparing nearby healthy
cells remains one of the most ambitious objectives in pharmacology. Nanomedicine, which …

An efficient method for Ir-catalyzed ligand free ortho borylation of arenes (such as, 2-
phenoxypyridines, 2-anilinopyridines, benzylamines, benzylpiperazines …