Skeletal muscle regeneration is a finely tuned process involving the activation of various
cellular and molecular processes. Satellite cells, the stem cells of skeletal muscle, are …

Background Colchicine is a widely used drug to treat inflammatory diseases. Due to its long
historical use in medicine, controlled clinical trials have been small and there remains some …

Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory
disease, but many rheumatologists are not well acquainted with its management. The …

Hyperuricemia has long been established as the major etiologic factor in gout. Alongside
with an inflammatory state triggered by urate crystal deposition in the joints, hyperuricemia …

Pericardial diseases can present clinically as acute pericarditis, pericardial effusion, cardiac
tamponade, and constrictive pericarditis. Patients can subsequently develop chronic or …

OBJECTIVES: To review recent advances in the understanding of molecular mechanisms of
drug disposition and cellular mechanisms of action and targets of colchicine, and disease …

Background Because patients with stable coronary artery disease are at continued risk of
major atherosclerotic events despite effective secondary prevention strategies, there is a …

Beside inherited muscle diseases many catabolic conditions such as insulin resistance,
malnutrition, cancer growth, aging, infections, chronic inflammatory status, inactivity, obesity …

New light has been shed on the mechanisms of action of colchicine in crystal-associated
arthropathies. Colchicine, long used to treat gout, arrests microtubule assembly and inhibits …

It has been recently demonstrated that interleukin 1β (IL-1β) plays a central role in
monosodium urate crystal–induced inflammation and that the NALP3 inflammasome plays a …