Abstract C3 glomerulopathy (C3G) is a rare and complex kidney disease that primarily
affects young adults. Renal outcomes remain poor in the absence of specific treatment. C3G …

Summary The C3 “Tickover” hypothesis, a mechanism whereby the host maintains constant
surveillance of potential invading pathogens, targeting them for elimination through …

Introduction Complement 3 glomerulopathy (C3G) is a rare inflammatory kidney disease
mediated by dysregulation of the alternative complement pathway. No targeted therapy …

Complement factor I (FI) is the nexus for classical, lectin and alternative pathway
complement regulation. FI is an 88kDa plasma protein that circulates in an inactive …

Nephritic factors (NeFs) are autoantibodies promoting the activity of the central enzymes of
the complement cascade, an important first line of defense of our innate immune system …

Abstract Background C3 glomerulopathy (C3G) is a complement-mediated disease.
Although genetic studies are not required for diagnosis, they are valuable for treatment …

Glomerular diseases are common causes of chronic kidney disease in childhood,
adolescence, and adulthood. The epidemiology of glomerular diseases differs between …

Abstract Background C3 glomerulopathy (C3G) and immune-complex
membranoproliferative glomerulonephritis (IC-MPGN) are rare disorders that frequently …

The field of complement kidney diseases is one of the fields of clinical nephrology in which
major strides have been made in recent decades. C3 glomerulopathy, a paradigmatic …

Recent progress in glomerular immune complex and complement-mediated diseases have
refined diagnostic categories and informed mechanistic understanding of disease …