Castleman's disease is a primary infectious disease of the lymph node that causes local
symptoms or a systemic inflammatory syndrome. Histopathology reveals a destroyed lymph …

Angiofollicular lymph node hyperplasia, known more commonly as Castleman disease, is a
rare lymphoproliferative disorder. Castleman disease has two distinct clinical manifestations …

Rituximab has revolutionized the treatment of Kaposi sarcoma–associated
herpesvirus/human herpesvirus 8–associated multicentric Castleman disease (HHV8+ …

HIV is a global pandemic. However, anti-retroviral therapy has transformed the prognosis
and, providing compliance is good, a normal life expectancy can be anticipated. This has led …

Multicentric Castleman Disease (MCD) is a lymphoproliferative disorder presenting with
heterogeneous pathological and clinical features. It comprises disease entities with a …

Abstract Human herpesvirus 8 (HHV‐8, also known as Kaposi sarcoma‐associated
herpesvirus or KSHV) is the etiologic agent of Kaposi sarcoma (KS) and primary effusion …

Background: Castleman disease (CD) encompasses a spectrum of rare disorders with
characteristic histopathological features. Unicentric CD (UCD) is a benign, local hyperplasia …

Objectives Treatment options for multicentric Castleman disease (MCD) remain limited. The
only FDA‐approved drug is siltuximab for idiopathic MCD (iMCD), but the response rate with …

Human herpesvirus (HHV)-8 is an oncogenic gamma herpesvirus that was first described in
1994 in Kaposi sarcoma lesions. HHV-8 is involved in the pathophysiological features of …

Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder with systemic
symptoms and poor prognosis and is characterized by an abnormal proliferation of …