Designing Multi-Antigen Vaccines Against Acinetobacter baumannii Using Systemic Approaches

MJ McConnell, AJ Martín-Galiano - Frontiers in Immunology, 2021 - frontiersin.org
Vaccines and monoclonal antibodies are promising approaches for preventing and treating
infections caused by multidrug resistant Acinetobacter baumannii. However, only partial …

[HTML][HTML] An integrated in silico based subtractive genomics and reverse vaccinology approach for the identification of novel vaccine candidate and chimeric vaccine …

K Khan, K Jalal, R Uddin - Genomics, 2022 - Elsevier
Salmonella typhi is notorious for causing enteric fever which is also known as typhoid fever.
It emerged as an extreme drug resistant strain that requires urgent attention to prevent its …

Application of TonB-dependent transporters in vaccine development of gram-negative bacteria

J Wang, K Xiong, Q Pan, W He, Y Cong - Frontiers in Cellular and …, 2021 - frontiersin.org
Multiple scarce nutrients, such as iron and nickel, are essential for bacterial growth. Gram-
negative bacteria secrete chelators to bind these nutrients from the environment …

Phenotypic characterization and heterogeneity among modern clinical isolates of Acinetobacter baumannii

A Valcek, C Philippe, C Whiteway, E Robino… - Microbiology …, 2023 - Am Soc Microbiol
Acinetobacter baumannii is an opportunistic pathogenic bacterium prioritized by WHO and
CDC because of its increasing antibiotic resistance. Heterogeneity among strains represents …

New putative vaccine candidates against Acinetobacter baumannii using the reverse vaccinology method

S Fereshteh, S Abdoli, F Shahcheraghi, S Ajdary… - Microbial …, 2020 - Elsevier
Infections caused by multi-drug resistance Acinetobacter baumannii are increasing
worldwide. Discovery of the vaccine against this bacterium as a cost-effective and preventive …

Outer Membrane Protein, Oma87 Prevents Acinetobacter baumannii Infection

I Rasooli, R Abdolhamidi, A Jahangiri… - International journal of …, 2020 - Springer
Acinetobacter baumannii is one of the most problematic pathogens in clinical settings.
Emerging of its antibiotic-resistant strains persuade researchers to find alternative treatment …

Facing the challenges of multidrug-resistant Acinetobacter baumannii: progress and prospects in the vaccine development

NA Mat Rahim, HY Lee, U Strych… - Human Vaccines & …, 2021 - Taylor & Francis
ABSTRACT In 2017, the World Health Organization (WHO) named A. baumannii as one of
the three antibiotic-resistant bacterial species on its list of global priority pathogens in dire …

Exploitation of two siderophore receptors, BauA and BfnH, for protection against Acinetobacter baumannii infection

Z Aghajani, I Rasooli, SL Mousavi Gargari - Apmis, 2019 - Wiley Online Library
Iron uptake system is expressed in early stages of Acinetobacter baumannii infections under
iron‐restricted conditions. This study is aimed at the evaluation of immuno‐protectivity of …

COVID-19 vaccine design using reverse and structural vaccinology, ontology-based literature mining and machine learning

A Huffman, E Ong, J Hur, A D'Mello… - Briefings in …, 2022 - academic.oup.com
Rational vaccine design, especially vaccine antigen identification and optimization, is critical
to successful and efficient vaccine development against various infectious diseases …

[HTML][HTML] Study of the immunogenicity of outer membrane protein A (ompA) gene from Acinetobacter baumannii as DNA vaccine candidate in vivo

H Ansari, M Tahmasebi-Birgani… - Iranian journal of …, 2019 - ncbi.nlm.nih.gov
Objective (s): Acinetobacter baumannii is one the most dangerous opportunistic pathogens
in hospitalized infections. This bacterium is resistant to 90% of commercial antibiotics …