Radiation-induced lung toxicity–cellular and molecular mechanisms of pathogenesis, management, and literature review

L Käsmann, A Dietrich, CA Staab-Weijnitz… - Radiation …, 2020 - Springer
Lung, breast, and esophageal cancer represent three common malignancies with high
incidence and mortality worldwide. The management of these tumors critically relies on …

Interstitial lung abnormalities at CT: subtypes, clinical significance, and associations with lung cancer

A Hata, T Hino, M Yanagawa, M Nishino, T Hida… - Radiographics, 2022 - pubs.rsna.org
Interstitial lung abnormality (ILA) is defined as an interstitial change detected incidentally on
CT images. It is seen in 4%–9% of smokers and 2%–7% of nonsmokers. ILA has a tendency …

Differentiation between immune checkpoint inhibitor‐related and radiation pneumonitis in lung cancer by CT radiomics and machine learning

J Cheng, Y Pan, W Huang, K Huang, Y Cui… - Medical …, 2022 - Wiley Online Library
Purpose Consolidation immunotherapy after completion of chemoradiotherapy has become
the standard of care for unresectable locally advanced non‐small cell lung cancer and can …

[HTML][HTML] Inhaled curcumin mesoporous polydopamine nanoparticles against radiation pneumonitis

T Chen, B Zhuang, Y Huang, Y Liu, B Yuan… - … Pharmaceutica Sinica B, 2022 - Elsevier
Radiation therapy is an effective method to kill cancer cells and shrink tumors using high-
energy X-ray or γ-ray. Radiation pneumonitis (RP) is one of the most serious complications …

Radiation versus immune checkpoint inhibitor associated pneumonitis: distinct radiologic morphologies

X Chen, K Sheikh, E Nakajima, CT Lin, J Lee… - The …, 2021 - academic.oup.com
Background Patients with non-small cell lung cancer may develop pneumonitis after thoracic
radiotherapy (RT) and immune checkpoint inhibitors (ICIs). We hypothesized that distinct …

Radiomics and dosiomics signature from whole lung predicts radiation pneumonitis: A model development study with prospective external validation and decision …

Z Zhang, Z Wang, M Yan, J Yu, A Dekker, L Zhao… - International Journal of …, 2023 - Elsevier
Purpose Radiation pneumonitis (RP) is one of the common side effects of radiation therapy
in the thoracic region. Radiomics and dosiomics quantify information implicit within medical …

[HTML][HTML] Safety of thoracic radiotherapy in patients with prior immune-related adverse events from immune checkpoint inhibitors

N Shaverdian, J Beattie, M Thor, M Offin… - Annals of …, 2020 - Elsevier
Background Immune checkpoint inhibitors (ICIs) and thoracic radiotherapy are increasingly
used to treat advanced cancers. Despite data indicating exaggerated radiation toxicities in …

Radiation and immune checkpoint inhibitor-mediated pneumonitis risk stratification in patients with locally advanced non-small cell lung cancer: role of functional lung …

HMT Thomas, DS Hippe, P Forouzannezhad… - Discover Oncology, 2022 - Springer
Background Patients undergoing chemoradiation and immune checkpoint inhibitor (ICI)
therapy for locally advanced non-small cell lung cancer (NSCLC) experience pulmonary …

Outcomes of proton therapy for non-small cell lung cancer in patients with interstitial pneumonia

S Hashimoto, H Iwata, Y Hattori, K Nakajima… - Radiation …, 2022 - Springer
Background Interstitial pneumonia (IP) is a disease with a poor prognosis. In addition, IP
patients are more likely to develop lung cancer. Since IP patients frequently develop …

Radiation-induced lung injury—what do we know in the era of modern radiotherapy?

M Konkol, P Śniatała, P Milecki - reports of Practical …, 2022 - journals.viamedica.pl
Radiation-induced lung injury (RILI) that is usually divided into an early radiation-induced
pneumonitis (RIP) and late chronic radiation-induced lung fibrosis (RILF) remains a clinically …