CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis

Y Jiang, J Zhao, R Li, Y Liu, L Zhou, C Wang… - Journal of Experimental …, 2022 - Springer
Background Ferroptosis is a novel form of iron-dependent cell death and participates in the
malignant progression of glioblastoma (GBM). Although circular RNAs (circRNAs) are found …

Epigenetic alterations in glioblastomas: Diagnostic, prognostic and therapeutic relevance

L Montella, M Cuomo, N Del Gaudio… - … Journal of Cancer, 2023 - Wiley Online Library
Glioblastoma, the most common and heterogeneous tumor affecting brain parenchyma, is
dismally characterized by a very poor prognosis. Thus, the search of new, more effective …

Exosomal circWDR62 promotes temozolomide resistance and malignant progression through regulation of the miR-370-3p/MGMT axis in glioma

X Geng, Y Zhang, X Lin, Z Zeng, J Hu, L Hao, J Xu… - Cell Death & …, 2022 - nature.com
Exosome-mediated delivery of circular RNAs (circRNAs) is implicated in cancer progression.
However, the role of exosomal circRNAs in the chemotherapy resistance of tumours remains …

New perspective on DNA response pathway (DDR) in glioblastoma, focus on classic biomarkers and emerging roles of ncRNAs

BO Pirlog, S Ilut, R Pirlog, P Chiroi, A Nutu… - Expert Reviews in …, 2023 - cambridge.org
Background Glioblastoma (GBM) is the most frequent type of primary brain cancer, having a
median survival of only 15 months. The current standard of care includes a combination of …

GAS5 attenuates the malignant progression of glioma stem-like cells by promoting E-cadherin

H Wang, D Wang, Y Shen, C Sun, Q Hu, L Jiang… - Cancer gene …, 2023 - nature.com
It has been widely reported that glioma stem-like cells (GSCs) serve a crucial role in the
malignant progression of glioma. In particular, recent studies have reported that long non …

Protein structuromics: A new method for protein structure–function crosstalk in glioma

N Xiao, W Yang, J Wang, J Li, R Zhao… - Proteins: Structure …, 2024 - Wiley Online Library
Glioma is a type of tumor that starts in the glial cells of the brain or spine. Since the 1800s,
when the disease was first named, its survival rates have always been unsatisfactory …

CircKPNB1 mediates a positive feedback loop and promotes the malignant phenotypes of GSCs via TNF-α/NF-κB signaling

Y Jiang, J Zhao, Y Liu, J Hu, L Gao, H Wang… - Cell Death & …, 2022 - nature.com
Glioma stem cells (GSCs) are a special kind of cells in GBM showing tumor initiation, self-
renewal, and multi-lineage differentiation abilities. Finding novel circRNAs related to GSCs …

Hypoxia-Inducible Factor-Dependent and Independent Mechanisms Underlying Chemoresistance of Hypoxic Cancer Cells

PWT Lee, LR Koseki, T Haitani, H Harada… - Cancers, 2024 - mdpi.com
Simple Summary In solid tumors, oxygen concentration varies between different regions.
Generally, while oxygen supply is sufficient in the vicinity of blood vessels, the concentration …

[HTML][HTML] The landscape of circRNAs in gliomas temozolomide resistance: Insights into molecular pathways

A Mafi, N Hedayati, S Kahkesh, S Khoshayand… - Non-coding RNA …, 2024 - Elsevier
As the deadliest type of primary brain tumor, gliomas represent a significant worldwide
health concern. Circular RNA (circRNA), a unique non-coding RNA molecule, seems to be …

Diterpenoid honatisine overcomes temozolomide resistance in glioblastoma by inducing mitonuclear protein imbalance through disruption of TFAM-mediated mtDNA …

Z Li, K Sai, G Ma, F Chen, X Xu, L Chen, S Wang, W Li… - Phytomedicine, 2024 - Elsevier
Background Glioblastoma (GBM) represents as the most formidable intracranial malignancy.
The systematic exploration of natural compounds for their potential applications in GBM …