Intercellular tight junctions represent a formidable barrier against paracellular drug
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …

New therapeutic agents such as proteins, peptides, and nucleic acid-based agents are
being developed every year, making it vital to find a non-invasive route such as nasal or …

Cyclosporine is an immunomodulatory drug commonly used for the treatment of mild-to-
severe dry eye syndrome as well as intermediate and posterior segment diseases as uveitis …

Given their safety and efficiency in protecting protein integrity, polysorbates (PSs) have been
the most widely used excipients for the stabilization of protein therapeutics for years. In …

The eye, being one of the most intricate organs in the human body, hosts numerous
anatomical barriers and clearance mechanisms. This highlights the importance of devising a …

Abstract Purpose A 3D-Bioplotter® was employed to 3D print (3DP) a humic acid-
polyquaternium 10 (HA-PQ10) controlled release fixed dose combination (FDC) tablet …

The aim of this study was to develop a novel drug delivery system using two biocompatible
copolymers of Solutol® HS15 and Soluplus® to improve solubility, oral bioavailability and …

Tacrolimus has shown efficacy in eye inflammatory diseases. However, due to the drug
lability, its formulation into a stable ophthalmic product remains a challenge. Tacrolimus …

Alzheimer's disease (AD) is a neurodegenerative disorder and the most relevant form of
dementia affecting people worldwide. AD was reported to be associated with increased …

Background Doxorubicin (DOX) is an anthracycline antibiotic that inhibits the growth of
several solid and hematologic malignant tumors. Increasing the targeting ability of DOX and …