Depression is a potentially life-threatening disorder affecting millions of people across the
globe. It is a huge burden to both the individual and society, costing over£ 9 billion in 2000 …

The selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed
pharmacological treatment for depression. Since their introduction many have considered …

A revision of the 2008 British Association for Psychopharmacology evidence-based
guidelines for treating depressive disorders with antidepressants was undertaken in order to …

Objectives High rates of healthcare worker (HCW) burn-out have led many to label it an
'epidemic'urgently requiring interventions. This prospective pilot study examined the efficacy …

Objectives. These guidelines are based on a first edition that was published in 2002, and
have been edited and updated with the available scientific evidence until September 2009 …

Recently there has been much debate on the true usefulness of antidepressant therapy
especially after the publication of a meta-analysis by Kirsch et al.(PLoS Medicine 2008, 5 …

Antidepressants represent the standard treatment for major depression. However, their
efficacy is variable and incomplete. A growing number of studies suggest that the …

Background Amitriptyline is a tricyclic antidepressant that was synthesised in 1960 and
introduced as early as 1961 in the USA, but is still regularly used. It has also been frequently …

Background: Antidepressants are amongst the most frequently prescribed medications.
More than a decade ago, our clinical research group applied a prototypic set of …

Research over the last two decades has established ketamine as a safe, effective, fast-
acting, and sustained antidepressant that significantly reduces adverse symptoms …