Sažetak Estrogens have long been known as important regulators of the female
reproductive functions; however, our understanding of the role estrogens play in the human …

Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …

Aberrant DNA hypermethylation contributes to myeloid leukemogenesis by silencing
structurally normal genes involved in hematopoiesis. MicroRNAs (miRNAs) are noncoding …

Myelodysplastic syndromes (MDSs) are clonal hematologic disorders that frequently
represent an intermediate disease stage before progression to acute myeloid leukemia …

Objective To provide an introduction to the concept of DNA methylation and its function in
normal cells, and to explain the possible mechanisms as to how abnormalities in this …

Colorectal cancer (CRC) arises as a consequence of the accumulation of genetic and
epigenetic alterations in colonic epithelial cells during neoplastic transformation. Epigenetic …

Methylation of DNA is a biochemical modification that can influence gene expression and is
involved in inactivating one of the two X chromosomes in women. Evidence that has …

Chronic myeloid leukemia (CML) is characterized by the presence of the BCR-ABL1 fusion
gene, which encodes a constitutive active tyrosine kinase considered to be the pathogenic …

Aberrant methylation of multiple CpG islands has been described in acute myeloid leukemia
(AML), but it is not known whether these are independent events or whether they reflect …

ACUTE LYMPHOBLASTIC leukemias (ALL) are charac-terized by clonal proliferation,
accumulation, and tissue infiltration of neoplastic cells. They are mainly regarded as …