Microfluidic systems for high-throughput and high-content screening using the nematode Caenorhabditis elegans

M Cornaglia, T Lehnert, MAM Gijs - Lab on a Chip, 2017 - pubs.rsc.org
In a typical high-throughput drug screening (HTS) process, up to millions of chemical
compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit …

Studying Parkinson's disease using Caenorhabditis elegans models in microfluidic devices

K Youssef, A Tandon, P Rezai - Integrative Biology, 2019 - academic.oup.com
Parkinson's disease (PD) is a progressive neurological disorder associated with the loss of
dopaminergic neurons (DNs) in the substantia nigra and the widespread accumulation of α …

Cell counting and velocity algorithms for hydrodynamic study of unsteady biological flows in micro-channels

F Torrisi, G Stella, FM Guarino, M Bucolo - Biomicrofluidics, 2023 - pubs.aip.org
In this paper, the combination of two algorithms, a cell counting algorithm and a velocity
algorithm based on a Digital Particle Image Velocimetry (DPIV) method, is presented to …

A review of biosensing techniques for detection of trace carcinogen contamination in food products

Z Li, Y Yu, Z Li, T Wu - Analytical and Bioanalytical Chemistry, 2015 - Springer
Carcinogen contaminations in the food chain, for example heavy metal ions, pesticides,
acrylamide, and mycotoxins, have caused serious health problems. A major objective of …

An integrated platform enabling optogenetic illumination of Caenorhabditis elegans neurons and muscular force measurement in microstructured environments

Z Qiu, L Tu, L Huang, T Zhu, V Nock, E Yu, X Liu… - …, 2015 - pubs.aip.org
Optogenetics has been recently applied to manipulate the neural circuits of Caenorhabditis
elegans (C. elegans) to investigate its mechanosensation and locomotive behavior, which is …

High-throughput light sheet imaging of adult and larval C. elegans Parkinson's disease model using a low-cost optofluidic device and a fluorescent microscope

F Rahimpouresfahani, N Tabatabaei, P Rezai - RSC advances, 2024 - pubs.rsc.org
Recent advancements at the interface of microfluidics technology and light sheet
fluorescence microscopy have opened the door for high-throughput and high-content …

Recent Advances and Trends in Microfluidic Platforms for C. elegans Biological Assays

F Kamili, H Lu - Annual Review of Analytical Chemistry, 2018 - annualreviews.org
Microfluidics has proven to be a key tool in quantitative biological research. The C. elegans
research community in particular has developed a variety of microfluidic platforms to …

Microfluidic device for analysis of gas-evoked neuronal sensing in C. elegans

L Hu, J Wang, X Feng, W Du, BF Liu - Sensors and Actuators B: Chemical, 2015 - Elsevier
It is a challenging task to realize gaseous stimulations on Caenorhabibditis elegans for in
vivo neuronal analysis of chemo-sensing, due to the difficulties in gas control and worm …

Immobilization of live Caenorhabditis elegans individuals using an ultra-thin polydimethylsiloxane microfluidic chip with water retention

M Suzuki, T Sakashita, T Funayama - JoVE (Journal of Visualized …, 2019 - jove.com
Radiation is widely used for biological applications and for ion-beam breeding, and among
these methods, microbeam irradiation represents a powerful means of identifying …

Comparative toxicity of lead (Pb2+), copper (Cu2+), and mixtures of lead and copper to zebrafish embryos on a microfluidic chip

Y Li, X Yang, Z Chen, B Zhang, J Pan, X Li, F Yang… - …, 2015 - pubs.aip.org
Investigations were conducted to determine acute effects of Pb 2+ and Cu 2+ presented
individually and collectively on zebrafish embryos. Aquatic safety testing requires a cheap …