Liver metastasis is a major cause of mortality for patients with colorectal cancer (CRC).
Mismatch repair–proficient (pMMR) CRCs make up about 95% of metastatic CRCs, and are …

Resistance to 5-Fluorouracil (5-Fu) chemotherapy is the main cause of treatment failure in
the cure of colon cancer. Therefore, there is an urgent need to explore a safe and effective …

Effective therapies are lacking for patients with advanced colorectal cancer (CRC). The CRC
tumor microenvironment has elevated metabolic waste products due to altered metabolism …

Cancer heterogeneity has posed a great challenge to traditional cancer treatment, with the
reappearance of cancer heterogeneity of inter and intra patients being especially critical …

Objective The protein post-translational modification (PTM) in host cells can be rewritten by
bacterial enzymes and represents an unprecedented mechanism in the communication …

Immunotherapies, especially the programmed cell death 1/programmed cell death ligand 1
(PD-1/PD-L1) inhibitors, have revolutionized the therapeutic strategies of various cancers …

Colorectal cancer (CRC) is a highly heterogeneous cancer and exploring novel therapeutic
options is a pressing issue that needs to be addressed. Here, we established human CRC …

Colorectal cancer (CRC) remains one of the top cancers in the world. Although early
detection improves the survival rate to around 90%, late detection would mean the need to …

Background The loss of tumor antigens and depletion of CD8 T cells caused by the PD-1/PD-
L1 pathway are important factors for tumor immune escape. In recent years, there has been …

We present the case of a patient with Lynch syndrome and metastatic colorectal carcinoma
(mCRC). The initial immunohistochemistry (IHC) test for deficient mismatch repair gave a …