Background The number of cancer cases is expected to increase by 40% in 20 years and
reach nearly 30 million new cases per year in 2040 [1]. Therefore, it is of utmost importance …

Gut microbiota play critical roles in the development of colorectal cancer (CRC) metastasis,
but the underlying mechanisms remain elusive. This review discusses the molecular …

Liver metastasis is the most fatal event of colon cancer patients. Warburg effect has been
long challenged by the fact of upregulated oxidative phosphorylation (OXPHOS), while its …

Chelerythrine chloride (CHE) is a benzodiazepine alkaloid derived from natural herbs with
significant anti‐tumor and anti‐inflammatory activities. However, the exact role and …

Background In recent years, the significance of the nervous system in the tumor
microenvironment has gained increasing attention. The bidirectional communication …

Inflammation is a response of the body to external stimuli (eg. chemical irritants, bacteria,
viruses, etc.), and when the stimuli are persistent, they tend to trigger chronic inflammation …

Methods accurately predicting the responses of colorectal cancer (CRC) and colorectal
cancer liver metastasis (CRLM) to personalized chemotherapy remain limited due to tumor …

Accurate polyp segmentation is important for the diagnosis and treatment of colon cancer. In
recent years, efforts have been made to improve the encoder-decoder framework by using …

Irinotecan (IRT), a classic clinical chemotherapeutic agent for treating colorectal cancer, has
been found to induce immunogenic cell death (ICD) while exerting cytotoxicity in tumor cells …

Simple Summary In this review, we aim to clarify the prognostic significance of the KRAS p.
G12C mutation in metastatic colorectal cancer, emphasizing its potential as a promising …