Highlights•Rho kinase signaling plays important roles in the cardiovascular system.•Rho
kinase signaling mediates cardiac hypertrophy, apoptosis and fibrosis.•Rho kinase signaling …

The present study investigated whether Rho-associated protein kinase (RhoA/ROCK)
signaling pathway inhibitor simvastatin inhibits matrix metalloproteinase 2 (MMP-2) activity …

Endothelial dysfunction is a major contributor to the pathogenesis of vascular disease in
diabetes mellitus and RhoA/Rho-kinase (ROCK) system appears to play a crucial role in this …

Background Ischemia is the main cause of cerebral ischemic stroke with a high mortality
rate, and it is affected by the dysfunction of circular RNAs. The underlying molecular …

Atrial fibrillation (AF) is an arrhythmia caused by disorganized electrical activity in the atria,
and it is an important cause of mortality and morbidity. There is a limited data about Rho/Rho …

Background: The causal factors underpinning the onset and progression of diabetic heart
disease (DHD) remain to be fully elucidated. Myocardial function is critically dependent on …

Background/Aim: Rho kinase is a downstream effector of Rho GTPase that is known to
regulate various pathological processes. The aim of this study was to evaluate the regulation …

Background: Acute myocardial infarction (AMI) and post-infarct heart failure (HF) are among
the leading causes of death and disability worldwide. As such, new treatments are urgently …