Prevention of anthracycline-induced cardiotoxicity: the good and bad of current and alternative therapies

NF Sangweni, D van Vuuren, L Mabasa… - Frontiers in …, 2022 - frontiersin.org
Doxorubicin (Dox)-induced cardiotoxicity (DIC) remains a serious health burden, especially
in developing countries. Unfortunately, the high cost of current preventative strategies has …

Ang-1 and VEGF: central regulators of angiogenesis

Y Zhao, B Yu, Y Wang, S Tan, Q Xu, Z Wang… - Molecular and Cellular …, 2024 - Springer
Abstract Angiopoietin-1 (Ang-1) and Vascular Endothelial Growth Factor (VEGF) are central
regulators of angiogenesis and are often inactivated in various cardiovascular diseases …

Palm Fruit (Phoenix dactylifera L.) Pollen Extract Inhibits Cancer Cell and Enzyme Activities and DNA and Protein Damage

HM Habib, EM El-Fakharany, H El-Gendi, MG El-Ziney… - Nutrients, 2023 - mdpi.com
Palm fruit pollen extract (PFPE) is a natural source of bioactive polyphenols. The primary
aim of the study was to determine the antioxidant, antimicrobial, anticancer, enzyme …

Metabolite profiling and Ameliorative effect of quince (Cydonia oblonga) leaves against doxorubicin induced cardiotoxicity in Wistar rats

E Hanan, N Hasan, S Zahiruddin, S Ahmad, V Sharma… - Food Bioscience, 2023 - Elsevier
Quince (Cydonia oblonga) leaves are traditionally reported to alleviate the risk of
cardiovascular disease. The study envisaged to explore the in vitro and in vivo …

Farnesol protects against cardiotoxicity caused by doxorubicin-induced stress, inflammation, and cell death: an in vivo study in wistar rats

AAM Alkhanjaf, MT Athar, Z Ullah, AMH Alsayhab… - Molecules, 2022 - mdpi.com
Doxorubicin (DOXO) is an antineoplastic drug that is used extensively in managing multiple
cancer types. However, DOXO-induced cardiotoxicity is a limiting factor for its widespread …

Protective effect of limonin against doxorubicin-induced cardiotoxicity via activating nuclear factor-like 2 and Sirtuin 2 signaling pathways

J Deng, M Huang, H Wu - Bioengineered, 2021 - Taylor & Francis
The anti-tumor and anti-inflammatory effects of limonin have been established, here, we aim
to explore whether limonin can induce protective effects against doxorubicin (DOX) …

Dexpanthenol ameliorates doxorubicin-induced lung injury by regulating endoplasmic reticulum stress and apoptosis

MY Tepebaşı, Hİ Büyükbayram, Ö Özmen… - Naunyn-Schmiedeberg's …, 2023 - Springer
Doxorubicin (DOX), which is used as a chemotherapeutic agent in the treatment of tumors,
has limited use due to its toxicity in various organs and tissues. One of the organs where …

MiR‐125b enhances doxorubicin‐induced cardiotoxicity by suppressing the nucleus‐cytoplasmic translocation of YAP via targeting STARD13

X Jin, W Yu, P Ye - Environmental toxicology, 2022 - Wiley Online Library
The clinical application of doxorubicin (Dox) is limited due to its cardiotoxicity, while the
pathogenesis remains to be fully understood. Recent studies have suggested that microRNA …

Protective effects and mechanisms of lycorine against adriamycin-induced cardiotoxicity

Z Wang, Y Chen, M Gu, Z Wu, B Ding, W Yang, X Wu… - Phytomedicine, 2022 - Elsevier
Background Adriamycin (ADR), a high-efficiency, broad-spectrum anthraquinone
chemotherapeutic agent, is currently used to treat various malignant tumors and can lead to …

Synergistic impacts of Montelukast and Klotho against doxorubicin-induced cardiac toxicity in Rats

HA Elnoury, SA Elgendy, SH Baloza… - Toxicology …, 2022 - academic.oup.com
Doxorubicin (DOX) is a powerful antitumor agent with a well-known cardiaotoxic side effects.
In the current study, the ameliorative combined impacts of montelukast (Mont) and Klotho …