Prevention of anthracycline-induced cardiotoxicity: the good and bad of current and alternative therapies
NF Sangweni, D van Vuuren, L Mabasa… - Frontiers in …, 2022 - frontiersin.org
Doxorubicin (Dox)-induced cardiotoxicity (DIC) remains a serious health burden, especially
in developing countries. Unfortunately, the high cost of current preventative strategies has …
in developing countries. Unfortunately, the high cost of current preventative strategies has …
Ang-1 and VEGF: central regulators of angiogenesis
Y Zhao, B Yu, Y Wang, S Tan, Q Xu, Z Wang… - Molecular and Cellular …, 2024 - Springer
Abstract Angiopoietin-1 (Ang-1) and Vascular Endothelial Growth Factor (VEGF) are central
regulators of angiogenesis and are often inactivated in various cardiovascular diseases …
regulators of angiogenesis and are often inactivated in various cardiovascular diseases …
Palm Fruit (Phoenix dactylifera L.) Pollen Extract Inhibits Cancer Cell and Enzyme Activities and DNA and Protein Damage
Palm fruit pollen extract (PFPE) is a natural source of bioactive polyphenols. The primary
aim of the study was to determine the antioxidant, antimicrobial, anticancer, enzyme …
aim of the study was to determine the antioxidant, antimicrobial, anticancer, enzyme …
Metabolite profiling and Ameliorative effect of quince (Cydonia oblonga) leaves against doxorubicin induced cardiotoxicity in Wistar rats
Quince (Cydonia oblonga) leaves are traditionally reported to alleviate the risk of
cardiovascular disease. The study envisaged to explore the in vitro and in vivo …
cardiovascular disease. The study envisaged to explore the in vitro and in vivo …
Farnesol protects against cardiotoxicity caused by doxorubicin-induced stress, inflammation, and cell death: an in vivo study in wistar rats
AAM Alkhanjaf, MT Athar, Z Ullah, AMH Alsayhab… - Molecules, 2022 - mdpi.com
Doxorubicin (DOXO) is an antineoplastic drug that is used extensively in managing multiple
cancer types. However, DOXO-induced cardiotoxicity is a limiting factor for its widespread …
cancer types. However, DOXO-induced cardiotoxicity is a limiting factor for its widespread …
Protective effect of limonin against doxorubicin-induced cardiotoxicity via activating nuclear factor-like 2 and Sirtuin 2 signaling pathways
J Deng, M Huang, H Wu - Bioengineered, 2021 - Taylor & Francis
The anti-tumor and anti-inflammatory effects of limonin have been established, here, we aim
to explore whether limonin can induce protective effects against doxorubicin (DOX) …
to explore whether limonin can induce protective effects against doxorubicin (DOX) …
Dexpanthenol ameliorates doxorubicin-induced lung injury by regulating endoplasmic reticulum stress and apoptosis
MY Tepebaşı, Hİ Büyükbayram, Ö Özmen… - Naunyn-Schmiedeberg's …, 2023 - Springer
Doxorubicin (DOX), which is used as a chemotherapeutic agent in the treatment of tumors,
has limited use due to its toxicity in various organs and tissues. One of the organs where …
has limited use due to its toxicity in various organs and tissues. One of the organs where …
MiR‐125b enhances doxorubicin‐induced cardiotoxicity by suppressing the nucleus‐cytoplasmic translocation of YAP via targeting STARD13
X Jin, W Yu, P Ye - Environmental toxicology, 2022 - Wiley Online Library
The clinical application of doxorubicin (Dox) is limited due to its cardiotoxicity, while the
pathogenesis remains to be fully understood. Recent studies have suggested that microRNA …
pathogenesis remains to be fully understood. Recent studies have suggested that microRNA …
Protective effects and mechanisms of lycorine against adriamycin-induced cardiotoxicity
Z Wang, Y Chen, M Gu, Z Wu, B Ding, W Yang, X Wu… - Phytomedicine, 2022 - Elsevier
Background Adriamycin (ADR), a high-efficiency, broad-spectrum anthraquinone
chemotherapeutic agent, is currently used to treat various malignant tumors and can lead to …
chemotherapeutic agent, is currently used to treat various malignant tumors and can lead to …
Synergistic impacts of Montelukast and Klotho against doxorubicin-induced cardiac toxicity in Rats
HA Elnoury, SA Elgendy, SH Baloza… - Toxicology …, 2022 - academic.oup.com
Doxorubicin (DOX) is a powerful antitumor agent with a well-known cardiaotoxic side effects.
In the current study, the ameliorative combined impacts of montelukast (Mont) and Klotho …
In the current study, the ameliorative combined impacts of montelukast (Mont) and Klotho …