[HTML][HTML] Emerging role of NRF2 in ROS-mediated tumor chemoresistance

D Xue, X Zhou, J Qiu - Biomedicine & pharmacotherapy, 2020 - Elsevier
Chemoresistance is a central cause for the tumor management failure. Cancer cells disrupt
the redox homeostasis through reactive oxygen species (ROS) regulatory mechanisms …

Biological effects of gyrophoric acid and other lichen derived metabolites, on cell proliferation, apoptosis and cell signaling pathways

M Mohammadi, L Bagheri, A Badreldin, P Fatehi… - Chemico-biological …, 2022 - Elsevier
Secondary metabolites from fungi, algae and lichens have remarkable biological activities
as antibiotics, fungicides, antiviral drugs, and cancer therapeutics. This review focuses on …

Lactobacillus plantarum Combined with Galactooligosaccharides Supplement: A Neuroprotective Regimen Against Neurodegeneration and Memory Impairment by …

W Wang, C Xu, X Zhou, L Zhang, L Gu… - Journal of Agricultural …, 2022 - ACS Publications
Probiotics and prebiotics have received attention in alleviating neurodegenerative diseases.
Lactobacillus plantarum (L. plantarum) 69-2 was combined with galactooligosaccharides …

Usnea Acid‐Incorporated Ca2+/Mn2+ Ions Reservoirs for Elevated Ion‐Interference Therapy through Synergetic Biocatalysis and Osmolarity Imbalance

P Zheng, B Ding, G Zhu, J Lin, C Li - Small, 2023 - Wiley Online Library
Ion‐interference therapy (IIT) utilizes ions to disturb intracellular biological processes and
has been received increasing attention in tumor treatments recently. However, the low …

Antioxidant and Cytotoxic Activities of Usnea barbata (L.) FH Wigg. Dry Extracts in Different Solvents

V Popovici, L Bucur, A Popescu, V Schröder… - Plants, 2021 - mdpi.com
Lichens represent a significant source of antioxidants due to numerous metabolites that can
reduce free radicals. Usnea barbata (L.) FH Wigg. has been recognized and used since …

Design, Characterization, and Anticancer and Antimicrobial Activities of Mucoadhesive Oral Patches Loaded with Usnea barbata (L.) FH Wigg Ethanol Extract F-UBE …

V Popovici, E Matei, GC Cozaru, L Bucur, CE Gîrd… - Antioxidants, 2022 - mdpi.com
The oral cavity's common pathologies are tooth decay, periodontal disease, and oral cancer;
oral squamous cell carcinoma (OSCC) is the most frequent oral malignancy, with a high …

Self-assembled maslinic acid attenuates doxorobucin induced cytotoxicity via Nrf2 signaling pathway: An in vitro and in silico study in human healthy cells

J Banerjee, SN Hasan, S Samanta, B Giri… - Cell Biochemistry and …, 2022 - Springer
The clinical applications of some well-known chemotherapeutic drugs for cancer treatment
have been restricted nowadays owing to their adverse effects on many physiological …

A comparative survey of anti-melanoma and anti-inflammatory potential of usnic acid enantiomers—A comprehensive in vitro approach

A Galanty, P Zagrodzki, J Gdula-Argasińska… - Pharmaceuticals, 2021 - mdpi.com
Usnic acid (UA) is a chiral lichen metabolite with an interesting pharmacological profile. The
aim of this study was to compare the anti-melanoma effect of (+)-UA and (−)-UA in an in vitro …

The pyrazole derivative of usnic acid inhibits the proliferation of pancreatic cancer cells in vitro and in vivo

M Gimła, A Pyrczak-Felczykowska, M Malinowska… - Cancer Cell …, 2023 - Springer
Background Pancreatic cancer is one of the leading causes of cancer death in Western
societies. Its late diagnosis and resistance to chemotherapies result in a high mortality rate; …

A fluorene derivative inhibits human hepatocellular carcinoma cells by ROS-mediated apoptosis, anoikis and autophagy

R Urade, WT Chang, CC Ko, RN Li, HM Yang… - Life Sciences, 2023 - Elsevier
Fluorene was previously reported to have anticancer activity against human cancer cells. In
this study, we examined the in vitro function of 9-methanesulfonylmethylene-2, 3-dimethoxy …