Allogeneic hematopoietic stem cell transplantation (alloSCT) is an important curative
therapy for high-risk hematological malignancies, but the development of severe and/or …

Objectives The coordinated immune response of the host is the key of the successful combat
of the body against SARS-CoV-2 infection and is decisive for the development and …

Surgical resection continues to be the mainstay treatment for solid cancers even though
chemotherapy and immunotherapy have significantly improved patient overall survival and …

Immunotherapy has become an emerging strategy for the treatment of cancer.
Immunotherapeutic drugs have been increasing for clinical treatment. Despite significant …

Gene regulatory networks ensure that important genes are expressed at precise levels.
When gene expression is sufficiently perturbed, it can lead to disease. To understand how …

Cytokines are powerful immune modulators that initiate signaling through receptor
dimerization, but natural cytokines have structural limitations as therapeutics. We present a …

Naive CD4+ T lymphocytes initially undergo antigen-specific activation to promote a broad-
spectrum response before adopting bespoke cytokine expression profiles shaped by …

INTRODUCTION Naïve T cells activated by cognate antigens and costimulation proliferate
and differentiate to effector T cells. The shift from a resting to a proliferative state entails …

Virtually all natural proteins are built from only 20 amino acids, and while this makes
possible all the functions they perform, the ability to encode other amino acids selected for …

Asthma is an inflammatory disease of the airways characterized by intermittent episodes of
wheezing, chest tightness, and cough. Many of the inflammatory pathways implicated in …