Electrical stimulation in bone tissue engineering treatments

L Leppik, KMC Oliveira, MB Bhavsar… - European Journal of …, 2020 - Springer
Electrical stimulation (EStim) has been shown to promote bone healing and regeneration
both in animal experiments and clinical treatments. Therefore, incorporating EStim into …

Three‐dimensional models of cancer for pharmacology and cancer cell biology: capturing tumor complexity in vitro/ex vivo

JA Hickman, R Graeser, R de Hoogt… - Biotechnology …, 2014 - Wiley Online Library
Cancers are complex and heterogeneous pathological “organs” in a dynamic interplay with
their host. Models of human cancer in vitro, used in cancer biology and drug discovery, are …

Engineering hydrogels as extracellular matrix mimics

H Geckil, F Xu, X Zhang, SJ Moon, U Demirci - Nanomedicine, 2010 - Future Medicine
Extracellular matrix (ECM) is a complex cellular environment consisting of proteins,
proteoglycans, and other soluble molecules. ECM provides structural support to mammalian …

Tissue engineering and regenerative medicine: history, progress, and challenges

F Berthiaume, TJ Maguire… - Annual review of …, 2011 - annualreviews.org
The past three decades have seen the emergence of an endeavor called tissue engineering
and regenerative medicine in which scientists, engineers, and physicians apply tools from a …

[HTML][HTML] Toward exosome-based therapeutics: isolation, heterogeneity, and fit-for-purpose potency

GR Willis, S Kourembanas, SA Mitsialis - Frontiers in cardiovascular …, 2017 - frontiersin.org
Exosomes are defined as submicron (30–150 nm), lipid bilayer-enclosed extracellular
vesicles (EVs), specifically generated by the late endosomal compartment through fusion of …

Bioprocessing of mesenchymal stem cells and their derivatives: Toward cell‐free therapeutics

J Phelps, A Sanati-Nezhad, M Ungrin… - Stem Cells …, 2018 - Wiley Online Library
Mesenchymal stem cells (MSCs) have attracted tremendous research interest due to their
ability to repair tissues and reduce inflammation when implanted into a damaged or …

Process engineering of human pluripotent stem cells for clinical application

M Serra, C Brito, C Correia, PM Alves - Trends in biotechnology, 2012 - cell.com
Human pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem
cells, constitute an extremely attractive tool for cell therapy. However, flexible platforms for …

Essential steps in bioprinting: From pre-to post-bioprinting

P Datta, A Barui, Y Wu, V Ozbolat, KK Moncal… - Biotechnology …, 2018 - Elsevier
An increasing demand for directed assembly of biomaterials has inspired the development
of bioprinting, which facilitates the assembling of both cellular and acellular inks into well …

Scalable stirred-suspension bioreactor culture of human pluripotent stem cells

DE Kehoe, D Jing, LT Lock… - Tissue Engineering Part …, 2010 - liebertpub.com
Advances in stem cell biology have afforded promising results for the generation of various
cell types for therapies against devastating diseases. However, a prerequisite for realizing …

Advances in cell culture: anchorage dependence

OW Merten - … Transactions of the Royal Society B …, 2015 - royalsocietypublishing.org
Anchorage-dependent cells are of great interest for various biotechnological applications.(i)
They represent a formidable production means of viruses for vaccination purposes at very …