[HTML][HTML] Guidance for statistical design and analysis of toxicological dose–response experiments, based on a comprehensive literature review

F Kappenberg, JC Duda, L Schürmeyer, O Gül… - Archives of …, 2023 - Springer
The analysis of dose–response, concentration–response, and time–response relationships
is a central component of toxicological research. A major decision with respect to the …

Revised guidance on the risk assessment of plant protection products on bees (Apis mellifera, Bombus spp. and solitary bees)

European Food Safety Authority (EFSA)… - EFSA …, 2023 - Wiley Online Library
Abstract The European Commission asked EFSA to revise the risk assessment for honey
bees, bumble bees and solitary bees. This guidance document describes how to perform …

[HTML][HTML] Basic concepts of mixture toxicity and relevance for risk evaluation and regulation

D Bloch, P Diel, B Epe, M Hellwig, A Lampen… - Archives of …, 2023 - Springer
Exposure to multiple substances is a challenge for risk evaluation. Currently, there is an
ongoing debate if generic “mixture assessment/allocation factors”(MAF) should be …

Update of the risk assessment of inorganic arsenic in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2024 - Wiley Online Library
Abstract The European Commission asked EFSA to update its 2009 risk assessment on
arsenic in food carrying out a hazard assessment of inorganic arsenic (iAs) and using the …

6: 2 chlorinated polyfluoroalkyl ether sulfonates exert stronger thyroid homeostasis disruptive effects in newborns than perfluorooctanesulfonate: evidence based on …

X Liu, L Zhang, J Liu, G Zaya, Y Wang… - Environmental …, 2023 - ACS Publications
Growing toxicologic evidence suggests that emerging perfluoroalkyl substances (PFASs),
like chlorinated polyfluoroalkyl ether sulfonate (Cl-PFESA), may be as toxic or more toxic …

[HTML][HTML] Drivers of divergent assessments of bisphenol-A hazards to semen quality by various European agencies, regulators and scientists

A Kortenkamp, O Martin, E Iacovidou… - International Journal of …, 2024 - Elsevier
The downward revision of the bisphenol A (BPA) Health-based Guidance Value (HBGV) by
the European Food Safety Authority (EFSA) has led to disagreements with other regulatory …

[HTML][HTML] Does REACH provide sufficient information to regulate substances toxic to reproduction?

GAM Eliesen, M Woutersen, J van Engelen… - Regulatory Toxicology …, 2023 - Elsevier
Hazard classification and risk assessment of substances, is essential to protect workers and
consumers from hazardous substances including reproductive toxicants. The ability to …

Risk assessment for Birds and Mammals

European Food Safety Authority (EFSA)… - EFSA …, 2023 - Wiley Online Library
Abstract The European Commission asked EFSA to revise the Guidance on the risk
assessment for birds and mammals. That guidance described how to perform risk …

[HTML][HTML] Risk assessment of isoeugenol in food based on benchmark dose—Response modeling

T Quentin, H Franke, DW Lachenmeier - Toxics, 2023 - mdpi.com
Isoeugenol has recently been evaluated as possibly carcinogenic (Group 2B) by the WHO
International Agency for Research on Cancer (IARC). In light of this evaluation, an updated …

[HTML][HTML] Cannabidiol safety considerations: Development of a potential acceptable daily intake value and recommended upper intake limits for dietary supplement use

RG Henderson, M Vincent, BN Rivera… - Regulatory toxicology …, 2023 - Elsevier
Consumer use of hemp-derived products continues to rise, underscoring the need to
establish evidence-based safety guidance. The present study sought to develop …