The SARS-CoV-2 global pandemic has seen rapid spread, disease morbidities and death
associated with substantive social, economic and societal impacts. Treatments rely on re …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell
response that most likely contributes to virus control in COVID-19 patients but may also …

CD4+ T cells play an important role in immune responses against pathogens and cancer
cells. Although their main task is to provide help to other effector immune cells, a growing …

Antiviral immunity often requires CD8+ cytotoxic T lymphocytes (CTLs) that actively migrate
and search for virus-infected targets. Regulatory T cells (Tregs) have been shown to …

Antiretroviral therapy (ART) transformed HIV from a life-threatening disease to a chronic
condition. However, eliminating the virus remains an elusive therapy goal. For several …

LAG-3 is a type I transmembrane protein expressed on immune cells, such as activated T
cells, and binds to MHC class II with high affinity. LAG-3 is an inhibitory receptor, and its …

Bluetongue virus (BTV) is an arbovirus transmitted by the bite of infected Culicoides midges
that affects domestic and wild ruminants producing great economic losses. The infection …

ABSTRACT PD-1-targeted therapies have shown modest antiviral effects in preclinical
models of chronic viral infection. Thus, novel therapy protocols are necessary to enhance T …

Cytotoxic T lymphocyte (CTL) motility is an important feature of effective CTL responses and
is impaired when CTLs become exhausted, eg during chronic retroviral infections. A …

As the novel severe acute respiratory syndrome coronavirus-2 related pandemic-Corona
Virus Disease 2019 (COVID-19) has emerged, decision making in the context of cancer …