Hallmarks of brain aging: adaptive and pathological modification by metabolic states
MP Mattson, TV Arumugam - Cell metabolism, 2018 - cell.com
During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …
Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases
Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …
Evidence that ageing yields improvements as well as declines across attention and executive functions
J Veríssimo, P Verhaeghen, N Goldman… - Nature Human …, 2022 - nature.com
Many but not all cognitive abilities decline during ageing. Some even improve due to lifelong
experience. The critical capacities of attention and executive functions have been widely …
experience. The critical capacities of attention and executive functions have been widely …
Neural dedifferentiation in the aging brain
JD Koen, MD Rugg - Trends in cognitive sciences, 2019 - cell.com
Many cognitive abilities decline with age even in the absence of detectable pathology.
Recent evidence indicates that age-related neural dedifferentiation, operationalized in terms …
Recent evidence indicates that age-related neural dedifferentiation, operationalized in terms …
Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer's disease
A Nobili, EC Latagliata, MT Viscomi… - Nature …, 2017 - nature.com
Alterations of the dopaminergic (DAergic) system are frequently reported in Alzheimer's
disease (AD) patients and are commonly linked to cognitive and non-cognitive symptoms …
disease (AD) patients and are commonly linked to cognitive and non-cognitive symptoms …
Norepinephrine ignites local hotspots of neuronal excitation: How arousal amplifies selectivity in perception and memory
Emotional arousal enhances perception and memory of high-priority information but impairs
processing of other information. Here, we propose that, under arousal, local glutamate levels …
processing of other information. Here, we propose that, under arousal, local glutamate levels …
Models of sustained attention
M Esterman, D Rothlein - Current opinion in psychology, 2019 - Elsevier
Highlights•Numerous neurocognitive factors contribute to sustained attention.•Attention
fluctuates alongside shifting arousal, effort, and resource allocation.•An information …
fluctuates alongside shifting arousal, effort, and resource allocation.•An information …
Scalable production of iPSC-derived human neurons to identify tau-lowering compounds by high-content screening
Lowering total tau levels is an attractive therapeutic strategy for Alzheimer's disease and
other tauopathies. High-throughput screening in neurons derived from human induced …
other tauopathies. High-throughput screening in neurons derived from human induced …
Declining locus coeruleus–dopaminergic and noradrenergic modulation of long-term memory in aging and Alzheimer's disease
MJ Dahl, A Kulesza, M Werkle-Bergner… - … & Biobehavioral Reviews, 2023 - Elsevier
Memory is essential in defining our identity by guiding behavior based on past experiences.
However, aging leads to declining memory, disrupting older adult's lives. Memories are …
However, aging leads to declining memory, disrupting older adult's lives. Memories are …
The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer's disease
Alzheimer's disease (AD) is neuropathologically characterized by the intracellular
accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β …
accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β …