[HTML][HTML] Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen

F Heidary, R Gharebaghi - The Journal of antibiotics, 2020 - nature.com
Ivermectin proposes many potentials effects to treat a range of diseases, with its
antimicrobial, antiviral, and anti-cancer properties as a wonder drug. It is highly effective …

[HTML][HTML] Ivermectin for prevention and treatment of COVID-19 infection: a systematic review, meta-analysis, and trial sequential analysis to inform clinical guidelines

A Bryant, TA Lawrie, T Dowswell… - American journal of …, 2021 - journals.lww.com
Ivermectin for Prevention and Treatment of COVID-19 Infectio... : American Journal of
Therapeutics Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic …

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

Y Zhou, Y Hou, J Shen, Y Huang, W Martin, F Cheng - Cell discovery, 2020 - nature.com
Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus
(SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead …

The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: A pilot, double-blind, placebo …

C Chaccour, A Casellas, A Blanco-Di Matteo… - …, 2021 - thelancet.com
Background Ivermectin inhibits the replication of SARS-CoV-2 in vitro at concentrations not
readily achievable with currently approved doses. There is limited evidence to support its …

The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer

SNY Yang, SC Atkinson, C Wang, A Lee… - Antiviral research, 2020 - Elsevier
Infection by RNA viruses such as human immunodeficiency virus (HIV)-1, influenza, and
dengue virus (DENV) represent a major burden for human health worldwide. Although RNA …

Drug repurposing for antimicrobial discovery

MA Farha, ED Brown - Nature microbiology, 2019 - nature.com
Antimicrobial resistance continues to be a public threat on a global scale. The ongoing need
to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens …

[HTML][HTML] In silico prediction of potential inhibitors for the main protease of SARS-CoV-2 using molecular docking and dynamics simulation based drug-repurposing

Y Kumar, H Singh, CN Patel - Journal of infection and public health, 2020 - Elsevier
Background The rapidly enlarging COVID-19 pandemic caused by the novel SARS-corona
virus-2 is a global public health emergency of an unprecedented level. Unfortunately no …

[HTML][HTML] Ivermectin and COVID-19: keeping rigor in times of urgency

C Chaccour, F Hammann… - The American journal …, 2020 - ncbi.nlm.nih.gov
Ivermectin is a widely used drug for the treatment and control of several neglected tropical
diseases. 1 The drug has an excellent safety profile, with more than 2.5 billion doses …

Drug repositioning: Progress and challenges in drug discovery for various diseases

Y Hua, X Dai, Y Xu, G Xing, H Liu, T Lu, Y Chen… - European Journal of …, 2022 - Elsevier
Compared with traditional de novo drug discovery, drug repurposing has become an
attractive drug discovery strategy due to its low-cost and high efficiency. Through a …

[HTML][HTML] Discovery and development of safe-in-man broad-spectrum antiviral agents

PI Andersen, A Ianevski, H Lysvand… - International Journal of …, 2020 - Elsevier
Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-
specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases …