In this review, we discuss the importance of capsaicin to the current understanding of
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …

The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known
for its sensitivity to pungent vanilloid compound (ie capsaicin) and noxious stimuli, including …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

With regard to the varied, nonculinary uses of hot pepper, there is apparently little new under
the sun. For example, Incas burned dried chili peppers to combat the invading Spaniards by …

▪ Abstract The detection of painful stimuli occurs primarily at the peripheral terminals of
specialized sensory neurons called nociceptors. These small-diameter neurons transduce …

A large number of pharmacological studies have used capsaicin as a tool to activate many
physiological systems, with an emphasis on pain research but also including functions such …

The neurobiology of itch, which is formally known as pruritus, and its interaction with pain
have been illustrated by the complexity of specific mediators, itch-related neuronal pathways …

Capsaicin, the pungent ingredient in chili peppers, produces intense burning pain in
humans. Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1) …

Transient receptor potential vanilloid 1 (TRPV1) is a calcium-permeable ion channel best
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …

The capsaicin receptor, VR1 (also known as TRPV1), is a ligand-gated ion channel
expressed on nociceptive sensory neurons that responds to noxious thermal and chemical …