Hypertension, thrombosis, kidney failure, and diabetes: is COVID-19 an endothelial disease? A comprehensive evaluation of clinical and basic evidence
The symptoms most commonly reported by patients affected by coronavirus disease (COVID-
19) include cough, fever, and shortness of breath. However, other major events usually …
19) include cough, fever, and shortness of breath. However, other major events usually …
Arginine and endothelial function
J Gambardella, W Khondkar, MB Morelli, X Wang… - Biomedicines, 2020 - mdpi.com
Arginine (L-arginine), is an amino acid involved in a number of biological processes,
including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide …
including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide …
Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells
Vascular endothelial cell (EC) function depends on appropriate organ-specific molecular
and cellular specializations. To explore genomic mechanisms that control this specialization …
and cellular specializations. To explore genomic mechanisms that control this specialization …
Vitamin C and cardiovascular disease: an update
MB Morelli, J Gambardella, V Castellanos, V Trimarco… - Antioxidants, 2020 - mdpi.com
The potential beneficial effects of the antioxidant properties of vitamin C have been
investigated in a number of pathological conditions. In this review, we assess both clinical …
investigated in a number of pathological conditions. In this review, we assess both clinical …
Effect of different classes of antihypertensive drugs on endothelial function and inflammation
IVG Silva, RC de Figueiredo, DRA Rios - International journal of …, 2019 - mdpi.com
Hypertension is characterized by structural and functional changes in blood vessels that
travel with increased arterial stiffness, vascular inflammation, and endothelial dysfunction …
travel with increased arterial stiffness, vascular inflammation, and endothelial dysfunction …
Dopamine outside the brain: The eye, cardiovascular system and endocrine pancreas
Dopamine (DA) and DA receptors (DR) have been extensively studied in the central nervous
system (CNS), but their role in the periphery is still poorly understood. Here we summarize …
system (CNS), but their role in the periphery is still poorly understood. Here we summarize …
CaMK4 gene deletion induces hypertension
G Santulli, E Cipolletta, D Sorriento… - Journal of the …, 2012 - Am Heart Assoc
Background The expression of calcium/calmodulin‐dependent kinase IV (CaMKIV) was
hitherto thought to be confined to the nervous system. However, a recent genome‐wide …
hitherto thought to be confined to the nervous system. However, a recent genome‐wide …
Endothelium-derived dopamine and 6-nitrodopamine in the cardiovascular system
R Zatz, G De Nucci - Physiology, 2024 - journals.physiology.org
The review deals with the release of endothelium-derived dopamine and 6-nitrodopamine (6-
ND) and its effects on isolated vascular tissues and isolated hearts. Basal release of both …
ND) and its effects on isolated vascular tissues and isolated hearts. Basal release of both …
Cardiac non-myocyte cells show enhanced pharmacological function suggestive of contractile maturity in stem cell derived cardiomyocyte microtissues
SM Ravenscroft, A Pointon, AW Williams… - Toxicological …, 2016 - academic.oup.com
The immature phenotype of stem cell derived cardiomyocytes is a significant barrier to their
use in translational medicine and pre-clinical in vitro drug toxicity and pharmacological …
use in translational medicine and pre-clinical in vitro drug toxicity and pharmacological …
Perivascular adipose tissue and vascular smooth muscle tone: friends or foes?
Perivascular adipose tissue (PVAT) is a specialized type of adipose tissue that surrounds
most mammalian blood vessels. PVAT is a metabolically active, endocrine organ capable of …
most mammalian blood vessels. PVAT is a metabolically active, endocrine organ capable of …