Hypertension, thrombosis, kidney failure, and diabetes: is COVID-19 an endothelial disease? A comprehensive evaluation of clinical and basic evidence

C Sardu, J Gambardella, MB Morelli, X Wang… - Journal of clinical …, 2020 - mdpi.com
The symptoms most commonly reported by patients affected by coronavirus disease (COVID-
19) include cough, fever, and shortness of breath. However, other major events usually …

Arginine and endothelial function

J Gambardella, W Khondkar, MB Morelli, X Wang… - Biomedicines, 2020 - mdpi.com
Arginine (L-arginine), is an amino acid involved in a number of biological processes,
including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide …

Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells

MF Sabbagh, JS Heng, C Luo, RG Castanon, JR Nery… - elife, 2018 - elifesciences.org
Vascular endothelial cell (EC) function depends on appropriate organ-specific molecular
and cellular specializations. To explore genomic mechanisms that control this specialization …

Vitamin C and cardiovascular disease: an update

MB Morelli, J Gambardella, V Castellanos, V Trimarco… - Antioxidants, 2020 - mdpi.com
The potential beneficial effects of the antioxidant properties of vitamin C have been
investigated in a number of pathological conditions. In this review, we assess both clinical …

Effect of different classes of antihypertensive drugs on endothelial function and inflammation

IVG Silva, RC de Figueiredo, DRA Rios - International journal of …, 2019 - mdpi.com
Hypertension is characterized by structural and functional changes in blood vessels that
travel with increased arterial stiffness, vascular inflammation, and endothelial dysfunction …

Dopamine outside the brain: The eye, cardiovascular system and endocrine pancreas

C Bucolo, GM Leggio, F Drago, S Salomone - Pharmacology & …, 2019 - Elsevier
Dopamine (DA) and DA receptors (DR) have been extensively studied in the central nervous
system (CNS), but their role in the periphery is still poorly understood. Here we summarize …

CaMK4 gene deletion induces hypertension

G Santulli, E Cipolletta, D Sorriento… - Journal of the …, 2012 - Am Heart Assoc
Background The expression of calcium/calmodulin‐dependent kinase IV (CaMKIV) was
hitherto thought to be confined to the nervous system. However, a recent genome‐wide …

Endothelium-derived dopamine and 6-nitrodopamine in the cardiovascular system

R Zatz, G De Nucci - Physiology, 2024 - journals.physiology.org
The review deals with the release of endothelium-derived dopamine and 6-nitrodopamine (6-
ND) and its effects on isolated vascular tissues and isolated hearts. Basal release of both …

Cardiac non-myocyte cells show enhanced pharmacological function suggestive of contractile maturity in stem cell derived cardiomyocyte microtissues

SM Ravenscroft, A Pointon, AW Williams… - Toxicological …, 2016 - academic.oup.com
The immature phenotype of stem cell derived cardiomyocytes is a significant barrier to their
use in translational medicine and pre-clinical in vitro drug toxicity and pharmacological …

Perivascular adipose tissue and vascular smooth muscle tone: friends or foes?

A Ahmed, A Bibi, M Valoti, F Fusi - Cells, 2023 - mdpi.com
Perivascular adipose tissue (PVAT) is a specialized type of adipose tissue that surrounds
most mammalian blood vessels. PVAT is a metabolically active, endocrine organ capable of …