Major depressive disorder (MDD), also referred to as depression, is one of the most common
psychiatric disorders with a high economic burden. The etiology of depression is still not …

Major depressive disorder (MDD) is a highly prevalent and disabling disorder. Despite the
many hypotheses proposed to understand the molecular pathophysiology of depression, it is …

Background Treatment resistant depression is a complex disorder and an important source
of morbidity and mortality. Identification of risk factors of resistance may be useful to improve …

Brain-derived neurotrophic factor (BDNF) has been studied as a biomarker of major
depressive disorder (MDD). Besides diagnostic biomarkers, clinically useful biomarkers can …

In spite of promising preclinical results there is a decreasing number of new registered
medications in major depression. The main reason behind this fact is the lack of confirmation …

Brain-Derived Neurotrophic Factor (BDNF) is crucial for various aspects of neuronal
development and function, including synaptic plasticity, neurotransmitter release, and …

Increasing evidence demonstrates a connection between growth factor function (including
brain-derived neurotrophic factor, BDNF), glucocorticoid levels (one of the steroid …

Although substance use and abuse may impact brain and behavior, it is still unclear why
some people become addicted while others do not. Neuroscientific theories explain …

This study aimed to investigate the influence of genetic variants in neuroplasticity-related
genes on antidepressant treatment phenotypes. The BDNF-TrkB signaling pathway, as well …

There is a high rate of misdiagnosis between major depressive disorder (MDD) and bipolar
disorder (BD) in clinical practice. Our previous work provided suggestive evidence for brain …