Delayed fractional dosing with RTS, S/AS01 improves humoral immunity to malaria via a balance of polyfunctional NANP6-and Pf16-specific antibodies
Background Malaria remains a key cause of mortality in low-income countries. RTS, S/AS01
is currently the most advanced malaria vaccine, demonstrating∼ 50% efficacy in controlled …
is currently the most advanced malaria vaccine, demonstrating∼ 50% efficacy in controlled …
Antibody targets and properties for complement-fixation against the circumsporozoite protein in malaria immunity
The Plasmodium falciparum circumsporozoite protein (CSP) forms the basis of leading
subunit malaria vaccine candidates. However, the mechanisms and specific targets of …
subunit malaria vaccine candidates. However, the mechanisms and specific targets of …
Complement in malaria immunity and vaccines
Developing efficacious vaccines for human malaria caused by Plasmodium falciparum is a
major global health priority, although this has proven to be immensely challenging over the …
major global health priority, although this has proven to be immensely challenging over the …
Acquisition of complement fixing antibodies targeting Plasmodium falciparum merozoites in infants and their mothers in Uganda
SE Mortazavi, A Lugaajju, M Nylander… - Frontiers in …, 2023 - frontiersin.org
Background Antibody-mediated complement fixation has previously been associated with
protection against malaria in naturally acquired immunity. However, the process of early-life …
protection against malaria in naturally acquired immunity. However, the process of early-life …
Advancements and challenges in developing malaria vaccines: Targeting multiple stages of the parasite life cycle
Malaria, caused by Plasmodium species, remains a major global health concern, causing
millions of deaths annually. While the introduction of the RTS, S vaccine has shown promise …
millions of deaths annually. While the introduction of the RTS, S vaccine has shown promise …
Correlates of malaria vaccine efficacy
DI Stanisic, MBB McCall - Expert Review of Vaccines, 2021 - Taylor & Francis
Introduction: An effective vaccine against malaria forms a global health priority. Both
naturally acquired immunity and sterile protection induced by irradiated sporozoite …
naturally acquired immunity and sterile protection induced by irradiated sporozoite …
Background malaria incidence and parasitemia during the three-dose RTS, S/AS01 vaccination series do not reduce magnitude of antibody response nor efficacy …
Abstract Background RTS, S/AS01 has been recommended by WHO for widespread
implementation in medium to high malaria transmission settings. Previous analyses have …
implementation in medium to high malaria transmission settings. Previous analyses have …
Multi-functional antibody profiling for malaria vaccine development and evaluation
Introduction A vaccine would greatly accelerate current global efforts toward malaria
elimination. While a partially efficacious vaccine has been achieved for Plasmodium …
elimination. While a partially efficacious vaccine has been achieved for Plasmodium …
[HTML][HTML] Serology for Plasmodium vivax surveillance: a novel approach to accelerate towards elimination
Plasmodium vivax is the most widespread causative agent of human malaria in the world.
Despite the ongoing implementation of malaria control programs, the rate of case reduction …
Despite the ongoing implementation of malaria control programs, the rate of case reduction …
Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique
L Sanchez, M Vidal, C Jairoce, R Aguilar, I Ubillos… - npj Vaccines, 2020 - nature.com
Abstract The RTS, S/AS01E vaccine has shown consistent but partial vaccine efficacy in a
pediatric phase 3 clinical trial using a 3-dose immunization schedule. A fourth-dose 18 …
pediatric phase 3 clinical trial using a 3-dose immunization schedule. A fourth-dose 18 …