Malaria transmission intensity likely modifies RTS, S/AS01 efficacy due to a rebound effect in Ghana, Malawi, and Gabon
Abstract Background RTS, S/AS01 is the first malaria vaccine to be approved and
recommended for widespread implementation by the World Health Organization (WHO) …
recommended for widespread implementation by the World Health Organization (WHO) …
Seven-year kinetics of RTS, S/AS01-induced anti-CSP antibodies in young Kenyan children
Abstract Background RTS, S/AS01, the leading malaria vaccine has been recommended by
the WHO for widespread immunization of children at risk. RTS, S/AS01-induced anti-CSP …
the WHO for widespread immunization of children at risk. RTS, S/AS01-induced anti-CSP …
A cutting-edge immunoinformatics approach for design of multi-epitope oral vaccine against dreadful human malaria
Human malaria is a pathogenic disease mainly caused by Plasmodium falciparum, which
was responsible for about 405,000 deaths globally in the year 2018. To date, several …
was responsible for about 405,000 deaths globally in the year 2018. To date, several …
Immune responses to malaria pre‐erythrocytic stages: implications for vaccine development
KM Abuga, W Jones‐Warner… - Parasite immunology, 2021 - Wiley Online Library
Radiation‐attenuated sporozoites induce sterilizing immunity and remain the'gold
standard'for malaria vaccine development. Despite practical challenges in translating these …
standard'for malaria vaccine development. Despite practical challenges in translating these …
Defining species-specific and conserved interactions of apical membrane protein 1 during erythrocyte invasion in malaria to inform multi-species vaccines
Plasmodium falciparum and P. vivax are the major causes of human malaria, and P.
knowlesi is an important additional cause in SE Asia. Binding of apical membrane antigen 1 …
knowlesi is an important additional cause in SE Asia. Binding of apical membrane antigen 1 …
RTS,S/AS01E immunization increases antibody responses to vaccine-unrelated Plasmodium falciparum antigens associated with protection against clinical malaria …
Background Vaccination and naturally acquired immunity against microbial pathogens may
have complex interactions that influence disease outcomes. To date, only vaccine-specific …
have complex interactions that influence disease outcomes. To date, only vaccine-specific …
[HTML][HTML] Modelling the roles of antibody titre and avidity in protection from Plasmodium falciparum malaria infection following RTS, S/AS01 vaccination
Anti-circumsporozoite antibody titres have been established as an essential indicator for
evaluating the immunogenicity and protective capacity of the RTS, S/AS01 malaria vaccine …
evaluating the immunogenicity and protective capacity of the RTS, S/AS01 malaria vaccine …
Impacts of ecology, parasite antigenic variation, and human genetics on RTS, S/AS01e malaria vaccine efficacy
Abstract Purpose of Review Global malaria elimination has little chance of success without
an effective vaccine. The first malaria vaccine, RTS, S/AS01e, demonstrated moderate …
an effective vaccine. The first malaria vaccine, RTS, S/AS01e, demonstrated moderate …
Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2
BD Wines, L Kurtovic, HM Trist, S Esparon… - Frontiers in …, 2022 - frontiersin.org
Joining a function-enhanced Fc-portion of human IgG to the SARS-CoV-2 entry receptor
ACE2 produces an antiviral decoy with strain transcending virus neutralizing activity. SARS …
ACE2 produces an antiviral decoy with strain transcending virus neutralizing activity. SARS …
Induction, decay, and determinants of functional antibodies following vaccination with the RTS, S malaria vaccine in young children
Background RTS, S is the first malaria vaccine recommended for implementation among
young children at risk. However, vaccine efficacy is modest and short-lived. Antibodies play …
young children at risk. However, vaccine efficacy is modest and short-lived. Antibodies play …