In silico analysis and prediction of immunogenic epitopes for pre-erythrocytic proteins of the deadly Plasmodium falciparum
Malaria is the deadliest parasitic disease in tropical and subtropical areas around the world,
with considerable morbidity and mortality, particularly due to the life-threatening …
with considerable morbidity and mortality, particularly due to the life-threatening …
[PDF][PDF] T-follicular helper cells in malaria infection and roles in antibody induction
Immunity to malaria is mediated by antibodies that block parasite replication to limit parasite
burden and prevent disease. Cytophilic antibodies have been consistently shown to be …
burden and prevent disease. Cytophilic antibodies have been consistently shown to be …
Poly I:C elicits broader and stronger humoral and cellular responses to a Plasmodium vivax circumsporozoite protein malaria vaccine than Alhydrogel in mice
TBL Costa-Gouvea, KS Francoso, RF Marques… - Frontiers in …, 2024 - frontiersin.org
Malaria remains a global health challenge, necessitating the development of effective
vaccines. The RTS, S vaccination prevents Plasmodium falciparum (Pf) malaria but is …
vaccines. The RTS, S vaccination prevents Plasmodium falciparum (Pf) malaria but is …
Beyond binding: the outcomes of antibody-dependent complement activation in human malaria
Antibody immunity against malaria is effective but non-sterile. In addition to antibody-
mediated inhibition, neutralisation or opsonisation of malaria parasites, antibody-mediated …
mediated inhibition, neutralisation or opsonisation of malaria parasites, antibody-mediated …
RTS, S/AS01E malaria vaccine induces IgA responses against CSP and vaccine-unrelated antigens in African children in the phase 3 trial
R Suau, M Vidal, R Aguilar, G Ruiz-Olalla… - Vaccine, 2021 - Elsevier
Background The evaluation of immune responses to RTS, S/AS01 has traditionally focused
on immunoglobulin (Ig) G antibodies that are only moderately associated with protection …
on immunoglobulin (Ig) G antibodies that are only moderately associated with protection …
Engineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria …
Novel approaches for malaria prophylaxis remain important. Synthetic DNA-encoded
monoclonal antibodies (DMAbs) are a promising approach to generate rapid, direct in vivo …
monoclonal antibodies (DMAbs) are a promising approach to generate rapid, direct in vivo …
Novel Virus-Like Particle Vaccine Encoding the Circumsporozoite Protein of Plasmodium falciparum Is Immunogenic and Induces Functional Antibody Responses in …
L Kurtovic, D Wetzel, L Reiling, DR Drew… - Frontiers in …, 2021 - frontiersin.org
RTS, S is the leading malaria vaccine in development, but has demonstrated only moderate
protective efficacy in clinical trials. RTS, S is a virus-like particle (VLP) that uses the human …
protective efficacy in clinical trials. RTS, S is a virus-like particle (VLP) that uses the human …
[HTML][HTML] The impact of human complement on the clinical outcome of malaria infection
The tropical disease malaria remains a major cause of global morbidity. Once transmitted to
the human by a blood-feeding mosquito, the unicellular malaria parasite comes into contact …
the human by a blood-feeding mosquito, the unicellular malaria parasite comes into contact …
Identification of first-in-class plasmodium OTU inhibitors with potent anti-malarial activity
OTU proteases antagonize the cellular defense in the host cells and involve in
pathogenesis. Intriguingly, P. falciparum, P. vivax, and P. yoelii have an uncharacterized and …
pathogenesis. Intriguingly, P. falciparum, P. vivax, and P. yoelii have an uncharacterized and …
Antibody-Dependent Respiratory Burst against Plasmodium falciparum Merozoites in Individuals Living in an Area with Declining Malaria Transmission
DD Mutemi, J Tuju, R Ogwang, L Nyamako… - Vaccines, 2024 - mdpi.com
Malaria transmission intensity affects the development of naturally acquired immunity to
malaria. An absolute correlate measure of protection against malaria is lacking. However …
malaria. An absolute correlate measure of protection against malaria is lacking. However …