Plasmodium falciparum Gametes and Sporozoites Hijack Plasmin and Factor H To Evade Host Complement Killing

M Ernest, TFA Rosa, ZR Pala, HM Kudyba… - Microbiology …, 2023 - Am Soc Microbiol
Plasmodium parasites are the etiological agents of malaria, a disease responsible for over
half a million deaths annually. Successful completion of the parasite's life cycle in the …

[HTML][HTML] Assessment of IgG3 as a serological exposure marker for Plasmodium vivax in areas with moderate–high malaria transmission intensity

Y Tayipto, J Rosado, D Gamboa, MT White… - Frontiers in Cellular …, 2022 - frontiersin.org
A more sensitive surveillance tool is needed to identify Plasmodium vivax infections for
treatment and to accelerate malaria elimination efforts. To address this challenge, our …

Previous Malaria Exposures and Immune Dysregulation: Developing Strategies To Improve Malaria Vaccine Efficacy in Young Children.

KR Dobbs, HE Atieli, C Valim… - The American Journal of …, 2024 - europepmc.org
After several decades in development, two malaria vaccines based on the same antigen and
with very similar constructs and adjuvants, RTS, S/AS01 (RTS, S) and R21/Matrix-M (R21) …

[PDF][PDF] Epitope masking may limit antibody boosting to malaria vaccines

L Kurtovic, MJ Boyle, JG Beeson - Immunology and Cell Biology, 2021 - researchgate.net
Malaria remains a significant threat to global health, responsible for more than 200 million
clinical cases and almost half a million deaths each year. 1 Leading malaria vaccine …

Fc-dependent functional activity of ChAdOx1-S and CoronaVac vaccine-induced antibodies to the SARS-CoV-2 spike protein

AW Harris, L Kurtovic, J Nogueira, I Bouzas, HD Opi… - medRxiv, 2023 - medrxiv.org
Ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and
COVID-19 disease severity is influenced by immunity acquired by natural exposure and/or …

[PDF][PDF] Analysis of the capability of IgG antibodies and receptors with their relationships to food tolerance and autoimmune disorders

A Ali, U Manzoor, SL Ali, R Nousheen… - … Journal of Natural …, 2023 - journals.iub.edu.pk
Analysis of the capability of IgG antibodies and receptors with their relationships to food
tolerance and autoimmune disorders Page 1 International Journal of Natural Medicine and …

[HTML][HTML] Novel sporozoite-based ELISpot assay to assess frequency of parasite-specific B cells after vaccination with irradiated sporozoites

T Atre, TM Robinson, T Savransky, S Dutta, JE Epstein… - Malaria Journal, 2019 - Springer
Background Whole parasite vaccination is an efficacious strategy to induce sterile immunity
and to prevent malaria transmission. Understanding the mechanism and response of …

Humoral Immune Responses to P. falciparum Circumsporozoite Protein (Pfcsp) Induced by the RTS, S Vaccine – Current Update

P Ngulube - Infection and Drug Resistance, 2023 - Taylor & Francis
Malaria vaccines targeting the circumsporozoite protein (CSP) of the P. falciparum parasite
have been overall relatively promising. RTS, S is a pre-erythrocytic recombinant protein …

[HTML][HTML] Malaria Transmission Intensity and Parasitemia during the Three-Dose RTS, S/AS01 Vaccination Series do not Reduce Magnitude of Antibody Response nor …

GJ Bell, S Gyaase, V Goel, B Adu, B Mensah… - Research …, 2023 - ncbi.nlm.nih.gov
Background: RTS, S/AS01 has been recommended by WHO for widespread implementation
in medium to high malaria transmission settings. Previous analyses have noted lower …

Investigating protective mechanisms of anti-sporozoite vaccines

DG Bellamy - 2023 - ora.ox.ac.uk
Malaria remains a leading cause of childhood mortality, thereby highlighting the need for an
effective vaccine. R21 is a virus-like particle-based (VLP-based) vaccine displaying the …