Plasmodium falciparum Gametes and Sporozoites Hijack Plasmin and Factor H To Evade Host Complement Killing
M Ernest, TFA Rosa, ZR Pala, HM Kudyba… - Microbiology …, 2023 - Am Soc Microbiol
Plasmodium parasites are the etiological agents of malaria, a disease responsible for over
half a million deaths annually. Successful completion of the parasite's life cycle in the …
half a million deaths annually. Successful completion of the parasite's life cycle in the …
[HTML][HTML] Assessment of IgG3 as a serological exposure marker for Plasmodium vivax in areas with moderate–high malaria transmission intensity
A more sensitive surveillance tool is needed to identify Plasmodium vivax infections for
treatment and to accelerate malaria elimination efforts. To address this challenge, our …
treatment and to accelerate malaria elimination efforts. To address this challenge, our …
Previous Malaria Exposures and Immune Dysregulation: Developing Strategies To Improve Malaria Vaccine Efficacy in Young Children.
KR Dobbs, HE Atieli, C Valim… - The American Journal of …, 2024 - europepmc.org
After several decades in development, two malaria vaccines based on the same antigen and
with very similar constructs and adjuvants, RTS, S/AS01 (RTS, S) and R21/Matrix-M (R21) …
with very similar constructs and adjuvants, RTS, S/AS01 (RTS, S) and R21/Matrix-M (R21) …
[PDF][PDF] Epitope masking may limit antibody boosting to malaria vaccines
Malaria remains a significant threat to global health, responsible for more than 200 million
clinical cases and almost half a million deaths each year. 1 Leading malaria vaccine …
clinical cases and almost half a million deaths each year. 1 Leading malaria vaccine …
Fc-dependent functional activity of ChAdOx1-S and CoronaVac vaccine-induced antibodies to the SARS-CoV-2 spike protein
AW Harris, L Kurtovic, J Nogueira, I Bouzas, HD Opi… - medRxiv, 2023 - medrxiv.org
Ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and
COVID-19 disease severity is influenced by immunity acquired by natural exposure and/or …
COVID-19 disease severity is influenced by immunity acquired by natural exposure and/or …
[PDF][PDF] Analysis of the capability of IgG antibodies and receptors with their relationships to food tolerance and autoimmune disorders
Analysis of the capability of IgG antibodies and receptors with their relationships to food
tolerance and autoimmune disorders Page 1 International Journal of Natural Medicine and …
tolerance and autoimmune disorders Page 1 International Journal of Natural Medicine and …
[HTML][HTML] Novel sporozoite-based ELISpot assay to assess frequency of parasite-specific B cells after vaccination with irradiated sporozoites
Background Whole parasite vaccination is an efficacious strategy to induce sterile immunity
and to prevent malaria transmission. Understanding the mechanism and response of …
and to prevent malaria transmission. Understanding the mechanism and response of …
Humoral Immune Responses to P. falciparum Circumsporozoite Protein (Pfcsp) Induced by the RTS, S Vaccine – Current Update
P Ngulube - Infection and Drug Resistance, 2023 - Taylor & Francis
Malaria vaccines targeting the circumsporozoite protein (CSP) of the P. falciparum parasite
have been overall relatively promising. RTS, S is a pre-erythrocytic recombinant protein …
have been overall relatively promising. RTS, S is a pre-erythrocytic recombinant protein …
[HTML][HTML] Malaria Transmission Intensity and Parasitemia during the Three-Dose RTS, S/AS01 Vaccination Series do not Reduce Magnitude of Antibody Response nor …
Background: RTS, S/AS01 has been recommended by WHO for widespread implementation
in medium to high malaria transmission settings. Previous analyses have noted lower …
in medium to high malaria transmission settings. Previous analyses have noted lower …
Investigating protective mechanisms of anti-sporozoite vaccines
DG Bellamy - 2023 - ora.ox.ac.uk
Malaria remains a leading cause of childhood mortality, thereby highlighting the need for an
effective vaccine. R21 is a virus-like particle-based (VLP-based) vaccine displaying the …
effective vaccine. R21 is a virus-like particle-based (VLP-based) vaccine displaying the …