Cardiovascular disease, a leading cause of mortality in developed countries, is mainly
caused by atherosclerosis, a chronic inflammatory disease. Macrophages, which …

The let-7 miRNA family plays a key role in modulating inflammatory responses. Vascular
smooth muscle cell (SMC) proliferation and endothelial cell (EC) dysfunction are critical in …

Chronic inflammation in response to lipoprotein accumulation in the arterial wall is central in
the development of atherosclerosis. Both innate and adaptive immunity are involved in this …

HIV-infected individuals have activated monocytes with an IFNα phenotype and elevated
levels of circulating LPS. These individuals also have a risk of premature cardiovascular …

Background Inflammation may contribute to the pathogenesis of various forms of pulmonary
hypertension (PH). Recent studies in patients with idiopathic PH or PH associated with …

OBJECTIVE: Atherosclerosis is a condition that is increasingly contributing to worldwide
mortality through complications such as stroke and myocardial infarction. IL-1β plays …

Clinical complications of atherosclerosis arise primarily as a result of luminal obstruction due
to atherosclerotic plaque growth, with inadequate outward vessel remodeling and plaque …

Nuts are energy-dense foods, rich in total fat and unsaturated fatty acids. The favorable fatty
acid profile probably contributes to the beneficial effects of nut consumption observed in …

Regulation of genes that initiate and amplify inflammatory programs of gene expression is
achieved by signal-dependent exchange of coregulator complexes that function to read …

Lysophosphatidylcholine (LPC) is a bioactive proinflammatory lipid generated by
pathological activities. LPC is also a major phospholipid component of oxidized low-density …